| Gene Information | |
|---|---|
| Gene Name | CENPW |
| Organism | Homo sapiens (Human) |
| Gene Length | 88 |
| Protein Names | Centromere protein W (CENP-W) (Cancer-up-regulated gene 2 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000203760 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q5EE01 |
| Gene Card | CENPW |
| Uniprot ID | Q5EE01 |
| Pfam | PF15510 |
| In ASD | no |
| Allosteric Prediction | no (-0.927906591) |
| Ortholog in Animals | Alpaca_ CENPW ( ortholog_one2one ) Dog_ CENPW ( ortholog_one2one ) GuineaPig_ CENPW ( ortholog_one2one ) Macaque_ CENPW ( ortholog_one2one ) Mouse_ Cenpw ( ortholog_one2one ) Pig_ CENPW ( ortholog_one2one ) Rat_ Cenpw ( ortholog_one2many ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in ovary, liver, lung and pancreas and to a lower extent in breast and gastrointestinal tract cancers; such as those of the colon, rectum and stomach. Overexpressed in high grade breast invasive tumors. Expressed in many cancer cell types. {ECO:0000269|PubMed:17079448, ECO:0000269|PubMed:17610844}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7QOO (EM 4.60A ) 7R5S (EM 2.83A ) 7YWX (EM 12.00A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:17610844}. Chromosome, centromere {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:19533040, ECO:0000269|PubMed:22304917}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19070575, ECO:0000269|PubMed:22304917}. Nucleus matrix {ECO:0000269|PubMed:22002061}. Nucleus, nucleolus {ECO:0000269|PubMed:22002061}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to the inner kinetochore during mitosis. {ECO:0000250|UniProtKB:P0DJH6}. |
| Mouse PG classification | NA |
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