| Gene Information | |
|---|---|
| Gene Name | CENPU |
| Organism | Homo sapiens (Human) |
| Gene Length | 418 |
| Protein Names | Centromere protein U (CENP-U) (Centromere protein of 50 kDa) (CENP-50) (Interphase centromere complex protein 24) (KSHV latent nuclear antigen-interacting protein 1) (MLF1-interacting protein) (Polo-box-interacting protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000151725 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q71F23 |
| Gene Card | CENPU |
| Uniprot ID | Q71F23 |
| Pfam | PF13097 |
| In ASD | no |
| Allosteric Prediction | no (-0.0694606) |
| Ortholog in Animals | Alpaca_ CENPU ( ortholog_one2one ) Dog_ CENPU ( ortholog_one2one ) GuineaPig_ CENPU ( ortholog_one2one ) Macaque_ CENPU ( ortholog_one2one ) Mouse_ Cenpu ( ortholog_one2one ) Pig_ CENPU ( ortholog_one2one ) Rat_ Cenpu ( ortholog_one2one ) Rabbit_ CENPU ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | testis |
| Tissue Specificity | Expressed at high levels in the testis, fetal liver, thymus, bone marrow and at lower levels in the lymph nodes, placenta, colon and spleen. Present in all cell lines examined, including B-cells, T-cells, epithelial cells and fibroblast cells. Expressed at high levels in glioblastoma cell lines. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:15116101, ECO:0000269|PubMed:15893739}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.053256(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7PB8 (X-ray 3.68A ) 7PKN (EM 3.20A ) 7QOO (EM 4.60A ) 7R5S (EM 2.83A ) 7R5V (EM 4.55A ) 7YWX (EM 12.00A ) 7YYH (EM 8.90A ) |
| DBSNP | rs902174 rs902174 rs6552804 rs4616798 rs34007339 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates. |
| Mouse PG classification | NA |
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