| Gene Information | |
|---|---|
| Gene Name | CENPK |
| Organism | Homo sapiens (Human) |
| Gene Length | 269 |
| Protein Names | Centromere protein K (CENP-K) (Interphase centromere complex protein 37) (Protein AF-5alpha) (p33) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123219 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9BS16 |
| Gene Card | CENPK |
| Uniprot ID | Q9BS16 |
| Pfam | PF11802 |
| In ASD | no |
| Allosteric Prediction | no (-0.648012494) |
| Ortholog in Animals | Alpaca_ CENPK ( ortholog_one2one ) Dog_ CENPK ( ortholog_one2one ) GuineaPig_ CENPK ( ortholog_one2one ) Macaque_ CENPK ( ortholog_one2one ) Mouse_ Cenpk ( ortholog_one2one ) Pig_ CENPK ( ortholog_one2one ) Rat_ Cenpk ( ortholog_one2one ) Rabbit_ CENPK ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Detected in several fetal organs with highest levels in fetal liver. In adults, it is weakly expressed in lung and placenta. {ECO:0000269|PubMed:8950979}. |
| Pharmacological Animal Models | 0.025380(Chimpanzee);0.137142(Mouse);0.002240(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7PB4 (X-ray 2.49A ) 7PKN (EM 3.20A ) 7QOO (EM 4.60A ) 7R5S (EM 2.83A ) 7R5V (EM 4.55A ) 7YWX (EM 12.00A ) 7YYH (EM 8.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. |
| Mouse PG classification | NA |
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