| Gene Information | |
|---|---|
| Gene Name | CASP5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 434 |
| Protein Names | Caspase-5 (CASP-5) (EC 3.4.22.58) (ICE(rel)-III) (Protease ICH-3) (Protease TY) [Cleaved into: Caspase-5 subunit p20; Caspase-5 subunit p10] |
| Target Name | caspase-5 |
| Target Type | Patented-recorded target |
| Gene Age | 886 ( ENSG00000137757 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P51878 |
| Gene Card | CASP5 |
| Uniprot ID | P51878 |
| Pfam | PF00619 |
| In ASD | yes |
| Allosteric Prediction | yes (0.538274486) |
| Ortholog in Animals | Alpaca_ CASP5 ( ortholog_one2one ) Macaque_ CASP5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PYCARD, CASP14, CASP8, CASP2, CASP6, CFLAR, CASP10, CARD18, CASP9, CASP1, CARD16, CASP3, CASP7, PYDC1, CASP12, CASP4 |
| Tissue | appendix, colon, duodenum, small.intestine, rectum |
| Tissue Specificity | Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. {ECO:0000269|PubMed:7797592}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs45483102 rs1792778 rs3181320 rs45585331 rs507879 rs3181179 rs3181326 rs45464699 rs523104 rs45619739 rs45458695 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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