| Gene Information | |
|---|---|
| Gene Name | HYAL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 435 |
| Protein Names | Hyaluronidase-1 (Hyal-1) (EC 3.2.1.35) (Hyaluronoglucosaminidase-1) (Lung carcinoma protein 1) (LuCa-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000114378 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q12794 |
| Gene Card | HYAL1 |
| Uniprot ID | Q12794 |
| Pfam | PF01630 |
| In ASD | no |
| Allosteric Prediction | yes (0.261961511) |
| Ortholog in Animals | Alpaca_ HYAL1 ( ortholog_one2one ) Dog_ HYAL1 ( ortholog_one2one ) GuineaPig_ HYAL1 ( ortholog_one2one ) Macaque_ HYAL1 ( ortholog_one2one ) Mouse_ Hyal1 ( ortholog_one2one ) Pig_ HYAL1 ( ortholog_one2one ) Rat_ Hyal1 ( ortholog_one2one ) Rabbit_ HYAL1 ( ortholog_one2one ) |
| Ohnologs | HYAL4, SPAM1 |
| Paralogs | HYAL3, HYAL4, HYAL2, SPAM1 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. {ECO:0000269|PubMed:10339581, ECO:0000269|PubMed:12084718, ECO:0000269|PubMed:9223416}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2PE4 (X-ray 2.00A ) |
| DBSNP | rs104893743 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:9223416}. Lysosome {ECO:0000269|PubMed:9223416}. |
| Mouse PG classification | NA |
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