| Gene Information | |
|---|---|
| Gene Name | CEL |
| Organism | Homo sapiens (Human) |
| Gene Length | 753 |
| Protein Names | Bile salt-activated lipase (BAL) (EC 3.1.1.13) (EC 3.1.1.3) (EC 3.1.1.6) (Bile salt-stimulated lipase) (BSSL) (Bucelipase) (Carboxyl ester lipase) (Cholesterol esterase) (Pancreatic lysophospholipase) (Sterol esterase) |
| Target Name | bile-salt-activated lipase |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000170835 ) |
| Evolutionary Stage | NA |
| AlphaFoldDB | P19835 |
| Gene Card | CEL |
| Uniprot ID | P19835 |
| Pfam | PF00135; PF16058 |
| In ASD | no |
| Allosteric Prediction | yes (0.434248413) |
| Ortholog in Animals | GuineaPig_ CEL ( ortholog_one2one ) Macaque_ CEL ( ortholog_one2one ) Mouse_ Cel ( ortholog_one2one ) Pig_ CEL ( ortholog_one2one ) Rat_ Cel ( ortholog_one2one ) Rabbit_ CEL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NLGN2, ACHE, NLGN4X, NLGN4Y, CES3, NLGN1, CES2, CES5A, CES4A, BCHE, TG, NLGN3, CES1 |
| Tissue | pancreas |
| Tissue Specificity | Mammary gland and pancreas. Detected in pancreatic and duodenal juice (at protein level) (PubMed:21784842). Expressed by eosinophils. {ECO:0000269|PubMed:11834744, ECO:0000269|PubMed:21784842}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F6W (X-ray 2.30A ) 1JMY (X-ray 2.60A ) 6H0T (X-ray 1.90A ) 6H0V (X-ray 2.20A ) 6H18 (X-ray 1.85A ) 6H19 (X-ray 1.89A ) 6H1A (X-ray 1.75A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:21784842}. |
| Mouse PG classification | NA |
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