| Gene Information | |
|---|---|
| Gene Name | CEBPB |
| Organism | Homo sapiens (Human) |
| Gene Length | 345 |
| Protein Names | CCAAT/enhancer-binding protein beta (C/EBP beta) (Liver activator protein) (LAP) (Liver-enriched inhibitory protein) (LIP) (Nuclear factor NF-IL6) (Transcription factor 5) (TCF-5) |
| Target Name | ccaat/enhancer-binding protein beta |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000172216 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P17676 |
| Gene Card | CEBPB |
| Uniprot ID | P17676 |
| Pfam | PF07716 |
| In ASD | no |
| Allosteric Prediction | yes (0.293543342) |
| Ortholog in Animals | Alpaca_ CEBPB ( ortholog_one2one ) Dog_ CEBPB ( ortholog_one2one ) GuineaPig_ CEBPB ( ortholog_one2one ) Macaque_ CEBPB ( ortholog_one2one ) Mouse_ Cebpb ( ortholog_one2one ) Pig_ CEBPB ( ortholog_one2one ) Rat_ Cebpb ( ortholog_one2one ) Rabbit_ CEBPB ( ortholog_one2one ) |
| Ohnologs | CEBPE |
| Paralogs | CEBPD, CEBPA, CEBPE, CEBPG |
| Tissue | NA |
| Tissue Specificity | Expressed at low levels in the lung, kidney and spleen. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.009624(Mouse);NULL(Rat);0.037500(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GTW (X-ray 1.85A ) 1GU4 (X-ray 1.80A ) 1GU5 (X-ray 2.10A ) 1H88 (X-ray 2.80A ) 1H89 (X-ray 2.45A ) 1H8A (X-ray 2.23A ) 1HJB (X-ray 3.00A ) 1IO4 (X-ray 3.00A ) 2E42 (X-ray 1.80A ) 2E43 (X-ray 2.10A ) 6MG1 (X-ray 1.75A ) 6MG2 (X-ray 1.93A ) 6MG3 (X-ray 2.05A ) 7L4V (X-ray 1.75A ) |
| DBSNP | rs4253440 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:20829347}. Cytoplasm {ECO:0000269|PubMed:9374525}. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). {ECO:0000250|UniProtKB:P28033, ECO:0000269|PubMed:9374525}. |
| Mouse PG classification | NA |
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