| Gene Information | |
|---|---|
| Gene Name | CEACAM5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 702 |
| Protein Names | Carcinoembryonic antigen-related cell adhesion molecule 5 (Carcinoembryonic antigen) (CEA) (Meconium antigen 100) (CD antigen CD66e) |
| Target Name | carcinoembryonic antigen cea |
| Target Type | Clinical trial target |
| Gene Age | 168 ( ENSG00000105388 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P06731 |
| Gene Card | CEACAM5 |
| Uniprot ID | P06731 |
| Pfam | PF13895; PF07686 |
| In ASD | no |
| Allosteric Prediction | no (-0.094467399) |
| Ortholog in Animals | Alpaca_ CEACAM5 ( ortholog_one2one ) Dog_ CEACAM1 ( ortholog_many2many ) Mouse_ Ceacam10 ( ortholog_many2many ) Mouse_ Ceacam1 ( ortholog_many2many ) Mouse_ Ceacam2 ( ortholog_many2many ) Rat_ Ceacam1 ( ortholog_many2many ) Rat_ Ceacam4 ( ortholog_many2many ) Rat_ Ceacam6 ( ortholog_many2many ) |
| Ohnologs | NA |
| Paralogs | CEACAM19, HEPACAM2, HEPACAM, VSTM5, CEACAM6, CEACAM1, CEACAM3, CEACAM7, CEACAM8, PSG1, PSG8, PSG9, PSG3, PSG7, PSG11, PSG2, PSG4, PSG5, PSG6, CEACAM4, CEACAM21, CEACAM16, CEACAM20, CEACAM18 |
| Tissue | appendix, colon, sigmoid.colon, small.intestine, transverse.colon |
| Tissue Specificity | Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421). Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon. {ECO:0000269|PubMed:10436421}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1E07 (X-ray - ) 2QSQ (X-ray 1.95A ) 2QST (X-ray 2.90A ) 2VER (NMR - ) |
| DBSNP | rs12971352 rs28683503 rs3815780 rs10407503 rs7249230 rs10423171 rs9621 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10864933, ECO:0000269|PubMed:18086185, ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}. |
| Mouse PG classification | NA |
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