| Gene Information | |
|---|---|
| Gene Name | CHRNB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 502 |
| Protein Names | Neuronal acetylcholine receptor subunit beta-2 |
| Target Name | neuronal acetylcholine (nach) receptor subunits |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000160716 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P17787 |
| Gene Card | CHRNB2 |
| Uniprot ID | P17787 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (1.127265785) |
| Ortholog in Animals | Alpaca_ CHRNB2 ( ortholog_one2one ) Dog_ CHRNB2 ( ortholog_one2one ) Macaque_ CHRNB2 ( ortholog_one2one ) Mouse_ Chrnb2 ( ortholog_one2one ) Pig_ CHRNB2 ( ortholog_one2one ) Rat_ Chrnb2 ( ortholog_one2one ) |
| Ohnologs | CHRNA3, CHRNB4, CHRNA2, CHRNB3, CHRNA6, CHRNA5 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GLRA3, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2K58 (NMR - ) 2K59 (NMR - ) 2KSR (NMR - ) 2LM2 (NMR - ) 5KXI (X-ray 3.94A ) 6CNJ (EM 3.40A ) 6CNK (EM 3.70A ) 6UR8 (EM 3.71A ) 6USF (EM 3.87A ) |
| DBSNP | rs74315291 rs74315291 rs55685423 |
| Subcellular location [CC] | Postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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