| Gene Information | |
|---|---|
| Gene Name | CDYL |
| Organism | Homo sapiens (Human) |
| Gene Length | 598 |
| Protein Names | Chromodomain Y-like protein (CDY-like) (Crotonyl-CoA hydratase) (EC 4.2.1.-) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000153046 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q9Y232 |
| Gene Card | CDYL |
| Uniprot ID | Q9Y232 |
| Pfam | PF00385; PF00378 |
| In ASD | no |
| Allosteric Prediction | no (-0.871702931) |
| Ortholog in Animals | Alpaca_ CDYL ( ortholog_one2one ) Dog_ CDYL ( ortholog_one2one ) GuineaPig_ CDYL ( ortholog_one2one ) Macaque_ CDYL ( ortholog_one2one ) Mouse_ Cdyl ( ortholog_one2one ) Pig_ CDYL ( ortholog_one2one ) Rat_ Cdyl ( ortholog_one2one ) Rabbit_ CDYL ( ortholog_one2one ) |
| Ohnologs | CDYL2 |
| Paralogs | ECI1, ECHS1, AUH, ECH1, CDYL2, ECHDC3, ECHDC2, HIBCH, ECHDC1, CDY1, CDY2A, CDY2B, CDY1B |
| Tissue | NA |
| Tissue Specificity | Expressed in the hippocampus with reduced expression in epileptic tissue compared to normal adjacent tissue (at protein level) (PubMed:28842554). Ubiquitous (PubMed:19808672). Expressed at moderate levels in all tissues examined (PubMed:19808672). Isoform 2: Most abundantly expressed isoform (PubMed:19808672). {ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:28842554}. |
| Pharmacological Animal Models | 0.022961(Chimpanzee);0.010239(Mouse);0.001466(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2DNT (NMR - ) 2GTR (X-ray 1.90A ) 7N27 (X-ray 1.85A ) |
| DBSNP | rs3812179 rs3812178 rs13196069 rs28360500 |
| Subcellular location [CC] | [Isoform 2]: Nucleus {ECO:0000269|PubMed:18450745, ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:29177481}. Chromosome {ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:29177481}. Note=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:19808672). Multimerization is required for chromatin-binding (PubMed:19808672). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). {ECO:0000269|PubMed:19808672, ECO:0000269|PubMed:29177481}. |
| Mouse PG classification | NA |
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