| Gene Information | |
|---|---|
| Gene Name | CDK5RAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1893 |
| Protein Names | CDK5 regulatory subunit-associated protein 2 (CDK5 activator-binding protein C48) (Centrosome-associated protein 215) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000136861 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q96SN8 |
| Gene Card | CDK5RAP2 |
| Uniprot ID | Q96SN8 |
| Pfam | PF07989 |
| In ASD | no |
| Allosteric Prediction | no (-0.377572263) |
| Ortholog in Animals | Alpaca_ CDK5RAP2 ( ortholog_one2one ) Dog_ CDK5RAP2 ( ortholog_one2one ) GuineaPig_ CDK5RAP2 ( ortholog_one2one ) Macaque_ CDK5RAP2 ( ortholog_one2one ) Mouse_ Cdk5rap2 ( ortholog_one2one ) Pig_ CDK5RAP2 ( ortholog_one2one ) Rat_ Cdk5rap2 ( ortholog_one2one ) Rabbit_ CDK5RAP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PDE4DIP |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:10721722}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.012366(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6X0V (EM 4.50A ) |
| DBSNP | rs13287734 rs4836822 rs3780679 rs7875294 rs4837768 rs16909747 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697, ECO:0000269|PubMed:31974111}. Golgi apparatus {ECO:0000269|PubMed:20466722}. Cytoplasm {ECO:0000269|PubMed:19553473}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573}. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localizes to microtubule plus ends in the presence of EB1/MAPRE1. Localization to centrosomes versus Golgi apparatus may be cell type-dependent. For instance, in SK-BR-3 and HEK293F cells, localizes to centrosomes but not to the Golgi apparatus (PubMed:29162697). {ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:29162697}. |
| Mouse PG classification | NA |
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