| Gene Information | |
|---|---|
| Gene Name | NOS3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 173 |
| Protein Names | Nanos homolog 3 (NOS-3) |
| Target Name | nitric oxide synthase, endothelial |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000164867 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P60323 |
| Gene Card | NANOS3 |
| Uniprot ID | P60323 |
| Pfam | PF05741 |
| In ASD | no |
| Allosteric Prediction | yes (1.39222894) |
| Ortholog in Animals | Alpaca_ NOS3 ( ortholog_one2one ) GuineaPig_ NOS3 ( ortholog_one2one ) Macaque_ NOS3 ( ortholog_one2one ) Mouse_ Nos3 ( ortholog_one2one ) Pig_ NOS3 ( ortholog_one2one ) Rat_ Nos3 ( ortholog_one2one ) Rabbit_ NOS3 ( ortholog_one2one ) |
| Ohnologs | NOS1 |
| Paralogs | POR, MTRR, NOS1, NDOR1, NOS2 |
| Tissue | spleen |
| Tissue Specificity | Ovary, testis and brain (at protein level). In the ovaries, expressed during multiple stages of oogenesis, including primordial, primary, secondary and antral follicles with the highest expression in the oocytes. In the testis, expressed in germ cells, type A spermatogonia (SA), primary spermatocytes (S1), round spermatids (S3) and elongated spermatids. {ECO:0000269|PubMed:21421998}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:21421998}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P60324}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P60324}. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000250|UniProtKB:P60324}. |
| Mouse PG classification | HPG |
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