| Gene Information | |
|---|---|
| Gene Name | CDS1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 543 |
| Protein Names | Serine/threonine-protein kinase Chk2 (EC 2.7.11.1) (CHK2 checkpoint homolog) (Cds1 homolog) (Hucds1) (hCds1) (Checkpoint kinase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000163624 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O96017 |
| Gene Card | CHEK2 |
| Uniprot ID | O96017 |
| Pfam | PF00498; PF00069 |
| In ASD | yes |
| Allosteric Prediction | no (-0.740354328) |
| Ortholog in Animals | Alpaca_ CDS1 ( ortholog_one2one ) Dog_ CDS1 ( ortholog_one2one ) GuineaPig_ CDS1 ( ortholog_one2one ) Macaque_ CDS1 ( ortholog_one2one ) Mouse_ Cds1 ( ortholog_one2one ) Pig_ CDS1 ( ortholog_one2one ) Rat_ Cds1 ( ortholog_one2one ) Rabbit_ CDS1 ( ortholog_one2one ) |
| Ohnologs | CDS2 |
| Paralogs | CDS2 |
| Tissue | NA |
| Tissue Specificity | High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.093905(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GXC (X-ray 2.70A ) 2CN5 (X-ray 2.25A ) 2CN8 (X-ray 2.70A ) 2W0J (X-ray 2.05A ) 2W7X (X-ray 2.07A ) 2WTC (X-ray 3.00A ) 2WTD (X-ray 2.75A ) 2WTI (X-ray 2.50A ) 2WTJ (X-ray 2.10A ) 2XBJ (X-ray 2.30A ) 2XK9 (X-ray 2.35A ) 2XM8 (X-ray 3.40A ) 2XM9 (X-ray 2.50A ) 2YCF (X-ray 1.77A ) 2YCQ (X-ray 2.05A ) 2YCR (X-ray 2.20A ) 2YCS (X-ray 2.35A ) 2YIQ (X-ray 1.89A ) 2YIR (X-ray 2.10A ) 2YIT (X-ray 2.20A ) 3I6U (X-ray 3.00A ) 3I6W (X-ray 3.25A ) 3VA4 (X-ray 1.54A ) 4A9R (X-ray 2.85A ) 4A9S (X-ray 2.66A ) 4A9T (X-ray 2.70A ) 4A9U (X-ray 2.48A ) 4BDA (X-ray 2.60A ) 4BDB (X-ray 2.50A ) 4BDC (X-ray 3.00A ) 4BDD (X-ray 2.67A ) 4BDE (X-ray 2.55A ) 4BDF (X-ray 2.70A ) 4BDG (X-ray 2.84A ) 4BDH (X-ray 2.70A ) 4BDI (X-ray 2.32A ) 4BDJ (X-ray 3.01A ) 4BDK (X-ray 3.30A ) |
| DBSNP | rs137853008 rs149991239 rs141568342 rs17883862 rs28909982 rs368570187 rs587781667 rs137853007 rs17879961 rs72552322 rs77130927 rs137853009 rs137853010 rs121908701 rs121908702 rs587780189 rs143611747 rs750984976 rs587780194 rs28909980 rs531398630 rs200928781 rs200649225 rs137853011 rs17882922 rs17880867 rs17881473 rs17886163 rs28909981 rs17883172 rs17882942 |
| Subcellular location [CC] | [Isoform 2]: Nucleus. Note=Isoform 10 is present throughout the cell.; [Isoform 4]: Nucleus.; [Isoform 7]: Nucleus.; [Isoform 9]: Nucleus.; [Isoform 12]: Nucleus.; Nucleus, PML body. Nucleus, nucleoplasm. Note=Recruited into PML bodies together with TP53. |
| Mouse PG classification | NA |
| click here to return to the previous page | |