| Gene Information | |
|---|---|
| Gene Name | MAGEA1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 309 |
| Protein Names | Melanoma-associated antigen 1 (Antigen MZ2-E) (Cancer/testis antigen 1.1) (CT1.1) (MAGE-1 antigen) |
| Target Name | melanoma-associated antigen 1 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000198681 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P43355 |
| Gene Card | MAGEA1 |
| Uniprot ID | P43355 |
| Pfam | PF01454; PF12440 |
| In ASD | no |
| Allosteric Prediction | no (-1.041980686) |
| Ortholog in Animals | Alpaca_ MAGEA1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MAGED4, MAGED4B, MAGEB17, MAGEB1, MAGEA3, MAGEA6, MAGEL2, MAGEA2, MAGEA2B, MAGEA12, NDN, MAGEB6, MAGEB6B, MAGEB2, MAGEH1, MAGEA8, MAGEE2, MAGEA11, MAGEB5, MAGED1, MAGEB10, MAGEA10, MAGEA4, TRO, MAGEB4, MAGEC3, MAGEE1, MAGEA9, MAGEA9B, MAGEB3, MAGEC1, MAGEC2, NSMCE3, MAGEB18, MAGEB16, MAGEF1, MAGED2 |
| Tissue | NA |
| Tissue Specificity | Expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes. Never expressed in kidney tumors, leukemias and lymphomas. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1W72 (X-ray 2.15A ) 3BO8 (X-ray 1.80A ) |
| DBSNP | rs2008160 rs2233044 rs2008144 |
| Subcellular location [CC] | Cytoplasm. Nucleus. |
| Mouse PG classification | NA |
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