| Gene Information | |
|---|---|
| Gene Name | KDM5C |
| Organism | Homo sapiens (Human) |
| Gene Length | 1560 |
| Protein Names | Lysine-specific demethylase 5C (EC 1.14.11.67) (Histone demethylase JARID1C) (Jumonji/ARID domain-containing protein 1C) (Protein SmcX) (Protein Xe169) ([histone H3]-trimethyl-L-lysine(4) demethylase 5C) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000126012 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P41229 |
| Gene Card | KDM5C |
| Uniprot ID | P41229 |
| Pfam | PF01388; PF02373; PF02375; PF00628; PF08429; PF02928 |
| In ASD | no |
| Allosteric Prediction | no (-0.333223365) |
| Ortholog in Animals | Alpaca_ KDM5C ( ortholog_one2one ) Dog_ KDM5C ( ortholog_one2one ) GuineaPig_ KDM5C ( ortholog_one2one ) Macaque_ KDM5C ( ortholog_one2one ) Mouse_ Kdm5c ( ortholog_one2one ) Pig_ KDM5C ( ortholog_one2one ) Rat_ Kdm5c ( ortholog_one2one ) Rabbit_ KDM5C ( ortholog_one2one ) |
| Ohnologs | KDM5A, KDM5B |
| Paralogs | JARID2, KDM4C, KDM4F, KDM4E, KDM4B, KDM4D, KDM5B, KDM4A, KDM5A, KDM5D |
| Tissue | NA |
| Tissue Specificity | Expressed in all tissues examined. Highest levels found in brain and skeletal muscle. {ECO:0000269|PubMed:15586325}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2JRZ (NMR - ) 5FWJ (X-ray 2.10A ) |
| DBSNP | rs199422235 rs199422237 rs1057518697 rs1057517955 rs199422234 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355, ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:17468742}. |
| Mouse PG classification | LPG |
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