Gene Information
Gene NameLAMP2
OrganismHomo sapiens (Human)
Gene Length410
Protein NamesLysosome-associated membrane glycoprotein 2 (LAMP-2) (Lysosome-associated membrane protein 2) (CD107 antigen-like family member B) (LGP-96) (CD antigen CD107b)
Target Namelysosome-associated membrane glycoprotein 2
Target TypeClinical trial target
Gene Age680 ( ENSG00000005893 )
Evolutionary StageVertebrata
AlphaFoldDBP13473
Gene CardLAMP2
Uniprot IDP13473
PfamPF01299
In ASDno
Allosteric Predictionno (-0.08974118)
Ortholog in AnimalsAlpaca_ LAMP2 ( ortholog_one2one )
Dog_ LAMP2 ( ortholog_one2one )
GuineaPig_ LAMP2 ( ortholog_one2one )
Macaque_ LAMP2 ( ortholog_one2one )
Mouse_ Lamp2 ( ortholog_one2one )
Pig_ LAMP2 ( ortholog_one2one )
Rat_ Lamp2 ( ortholog_one2one )
Rabbit_ LAMP2 ( ortholog_one2one )
OhnologsLAMP1
ParalogsLAMP1, CD68, LAMP5
TissueNA
Tissue SpecificityIsoform LAMP-2A is highly expressed in placenta, lung and liver, less in kidney and pancreas, low in brain and skeletal muscle (PubMed:7488019, PubMed:26856698). Isoform LAMP-2B is detected in spleen, thymus, prostate, testis, small intestine, colon, skeletal muscle, brain, placenta, lung, kidney, ovary and pancreas and liver (PubMed:7488019, PubMed:26856698). Isoform LAMP-2C is detected in small intestine, colon, heart, brain, skeletal muscle, and at lower levels in kidney and placenta (PubMed:26856698). {ECO:0000269|PubMed:26856698, ECO:0000269|PubMed:7488019}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2MOF  (NMR  -  )  2MOM  (NMR  -  ) 
DBSNP rs1043878  rs104894859 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:2912382};
Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Endosome membrane {ECO:0000269|PubMed:17897319};
Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Lysosome membrane {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:18644871, ECO:0000269|PubMed:2912382};
Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740, ECO:0000269|PubMed:17897319}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P17047}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane.
Mouse PG classificationHPG
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