| Gene Information | |
|---|---|
| Gene Name | CDKN6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 326 |
| Protein Names | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q00534 |
| Gene Card | CDK6 |
| Uniprot ID | Q00534 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed ubiquitously. Accumulates in squamous cell carcinomas, proliferating hematopoietic progenitor cells, beta-cells of pancreatic islets of Langerhans, and neuroblastomas. Reduced levels in differentiating cells. {ECO:0000269|PubMed:20668294, ECO:0000269|PubMed:8114739}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002704(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1BI7 (X-ray 3.40A ) 1BI8 (X-ray 2.80A ) 1BLX (X-ray 1.90A ) 1G3N (X-ray 2.90A ) 1JOW (X-ray 3.10A ) 1XO2 (X-ray 2.90A ) 2EUF (X-ray 3.00A ) 2F2C (X-ray 2.80A ) 3NUP (X-ray 2.60A ) 3NUX (X-ray 2.70A ) 4AUA (X-ray 2.31A ) 4EZ5 (X-ray 2.70A ) 4TTH (X-ray 2.90A ) 5L2I (X-ray 2.75A ) 5L2S (X-ray 2.27A ) 5L2T (X-ray 2.37A ) 6OQL (X-ray 2.71A ) 6OQO (X-ray 1.98A ) |
| DBSNP | rs35654944 rs606231255 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Cell projection, ruffle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:23918663}. Note=Localized to the ruffling edge of spreading fibroblasts. Kinase activity only in nucleus. Localized to the cytosol of neurons and showed prominent staining around either side of the nucleus (By similarity). Present in the cytosol and in the nucleus in interphase cells and at the centrosome during mitosis from prophase to telophase (PubMed:23918663). {ECO:0000250|UniProtKB:Q64261, ECO:0000269|PubMed:23918663}. |
| Mouse PG classification | NA |
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