Gene Information
Gene NameSMOX
OrganismHomo sapiens (Human)
Gene Length555
Protein NamesSpermine oxidase (EC 1.5.3.16) (Polyamine oxidase 1) (PAO-1) (PAOh1)
Target Namespermine oxidase
Target TypeNA
Gene Age1714 ( ENSG00000088826 )
Evolutionary StageEuk+Bac
AlphaFoldDBQ9NWM0
Gene CardSMOX
Uniprot IDQ9NWM0
PfamPF01593
In ASDyes
Allosteric Predictionyes (0.105885471)
Ortholog in AnimalsAlpaca_ SMOX ( ortholog_one2one )
Dog_ SMOX ( ortholog_one2one )
GuineaPig_ SMOX ( ortholog_one2one )
Macaque_ SMOX ( ortholog_one2one )
Mouse_ Smox ( ortholog_one2one )
Pig_ SMOX ( ortholog_one2one )
Rat_ RGD1564480 ( ortholog_one2many )
Rat_ Smox ( ortholog_one2many )
Rabbit_ SMOX ( ortholog_one2one )
OhnologsPAOX
ParalogsKDM1A, MAOA, PPOX, KDM1B, PAOX, MAOB, IL4I1
TissueNA
Tissue SpecificityWidely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line. {ECO:0000269|PubMed:18422650}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7OXL  (X-ray  2.40A  7OY0  (X-ray  2.09A 
DBSNP rs6084654 
Subcellular location [CC][Isoform 1]: Cytoplasm. Nucleus.;
[Isoform 4]: Cytoplasm. Nucleus.;
[Isoform 6]: Cytoplasm. Nucleus.
Mouse PG classificationNA
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