| Gene Information | |
|---|---|
| Gene Name | CDKN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 156 |
| Protein Names | Cyclin-dependent kinase inhibitor 2A (Cyclin-dependent kinase 4 inhibitor A) (CDK4I) (Multiple tumor suppressor 1) (MTS-1) (p16-INK4a) (p16-INK4) (p16INK4A) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P42771 |
| Gene Card | CDKN2A |
| Uniprot ID | P42771 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed but not detected in brain or skeletal muscle. Isoform 3 is pancreas-specific. {ECO:0000269|PubMed:10445844}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.023256(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A5E (NMR - ) 1BI7 (X-ray 3.40A ) 1DC2 (NMR - ) 2A5E (NMR - ) 7OZT (X-ray 1.74A ) |
| DBSNP | rs1819961127 rs864622263 rs760065045 rs760065045 rs1064794292 rs104894097 rs104894097 rs878853650 rs746834149 rs746834149 rs746834149 rs199907548 rs199907548 rs587778189 rs104894095 rs104894109 rs372266620 rs104894099 rs769382085 rs36204594 rs758389471 rs876658534 rs1060501260 rs372670098 rs559848002 rs760640852 rs200429615 rs760640852 rs1057519883 rs11552823 rs1334828764 rs34968276 rs121913385 rs11552822 rs11552822 rs878853646 rs878853647 rs749714198 rs137854599 rs137854597 rs1819703656 rs752685118 rs754806883 rs754806883 rs34886500 rs104894094 rs137854598 rs35741010 rs1554654024 rs370823171 rs121913381 rs121913386 rs104894104 rs1554653960 rs113798404 rs113798404 rs6413463 rs34170727 rs747621669 rs104894098 rs6413464 rs757497674 rs1587330478 rs116150891 rs3731249 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17658461}. Nucleus {ECO:0000269|PubMed:17658461}. |
| Mouse PG classification | NA |
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