| Gene Information | |
|---|---|
| Gene Name | CDKN1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 164 |
| Protein Names | Cyclin-dependent kinase inhibitor 1 (CDK-interacting protein 1) (Melanoma differentiation-associated protein 6) (MDA-6) (p21) |
| Target Name | cyclin-dependent kinase inhibitor 1 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000124762 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P38936 |
| Gene Card | CDKN1A |
| Uniprot ID | P38936 |
| Pfam | PF02234 |
| In ASD | no |
| Allosteric Prediction | yes (0.44502201) |
| Ortholog in Animals | Alpaca_ CDKN1A ( ortholog_one2one ) GuineaPig_ CDKN1A ( ortholog_one2one ) Macaque_ CDKN1A ( ortholog_one2one ) Mouse_ Cdkn1a ( ortholog_one2one ) Pig_ CDKN1A ( ortholog_one2one ) Rat_ Cdkn1a ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDKN1C, CDKN1B |
| Tissue | NA |
| Tissue Specificity | Expressed in all adult tissues, with 5-fold lower levels observed in the brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.056338(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1AXC (X-ray 2.60A ) 2ZVV (X-ray 2.00A ) 2ZVW (X-ray 2.50A ) 4RJF (X-ray 2.01A ) 5E0U (X-ray 1.93A ) 6CBI (X-ray 2.75A ) 6CEJ (NMR - ) 6CIV (NMR - ) 6CIX (NMR - ) 6P8H (X-ray 3.19A ) 7KQ0 (X-ray 2.40A ) 7KQ1 (X-ray 3.30A ) |
| DBSNP | rs4986866 rs1801270 rs4986867 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11463845}. Nucleus {ECO:0000269|PubMed:11463845, ECO:0000269|PubMed:23213251}. |
| Mouse PG classification | NA |
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