| Gene Information | |
|---|---|
| Gene Name | DAZAP2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 168 |
| Protein Names | DAZ-associated protein 2 (Deleted in azoospermia-associated protein 2) (Proline-rich transcript in brain protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000183283 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15038 |
| Gene Card | DAZAP2 |
| Uniprot ID | Q15038 |
| Pfam | PF11029 |
| In ASD | no |
| Allosteric Prediction | no (-1.381052161) |
| Ortholog in Animals | Alpaca_ DAZAP2 ( ortholog_one2one ) Dog_ DAZAP2 ( ortholog_one2one ) GuineaPig_ DAZAP2 ( ortholog_one2one ) Macaque_ DAZAP2 ( ortholog_one2one ) Mouse_ Dazap2 ( ortholog_one2one ) Pig_ DAZAP2 ( ortholog_one2one ) Rat_ Dazap2 ( ortholog_one2one ) Rabbit_ DAZAP2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma. {ECO:0000269|PubMed:10857750}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs57917280 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17935665, ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:19304756, ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:33591310}. Nucleus {ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:19304756, ECO:0000269|PubMed:21274613, ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:33591310}. Nucleus speckle {ECO:0000269|PubMed:11342538}. Nucleus, nuclear body {ECO:0000269|PubMed:33591310}. Cytoplasm, Stress granule {ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:33591310}. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm (PubMed:22070932). Predominantly cytoplasmic when unphosphorylated and localizes to the nucleus following phosphorylation by HIPK2 (PubMed:33591310). Localizes to stress granules under cellular stress conditions (PubMed:17984221). {ECO:0000269|PubMed:17984221, ECO:0000269|PubMed:22070932, ECO:0000269|PubMed:33591310}. |
| Mouse PG classification | NA |
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