| Gene Information | |
|---|---|
| Gene Name | CDKAL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | Threonylcarbamoyladenosine tRNA methylthiotransferase (EC 2.8.4.5) (CDK5 regulatory subunit-associated protein 1-like 1) (tRNA-t(6)A37 methylthiotransferase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000145996 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q5VV42 |
| Gene Card | CDKAL1 |
| Uniprot ID | Q5VV42 |
| Pfam | PF04055; PF01938; PF00919 |
| In ASD | no |
| Allosteric Prediction | no (-0.411027738) |
| Ortholog in Animals | Alpaca_ CDKAL1 ( ortholog_one2one ) Dog_ CDKAL1 ( ortholog_one2one ) GuineaPig_ CDKAL1 ( ortholog_one2one ) Macaque_ CDKAL1 ( ortholog_one2one ) Mouse_ Cdkal1 ( ortholog_one2one ) Pig_ CDKAL1 ( ortholog_one2one ) Rat_ Cdkal1 ( ortholog_one2one ) Rabbit_ CDKAL1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDK5RAP1 |
| Tissue | NA |
| Tissue Specificity | Expressed in pancreatic islets. {ECO:0000269|PubMed:23048041}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs9460608 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:23048041}; Single-pass membrane protein {ECO:0000255}. Note=Is a tail-anchored protein that exploits the TCR40 pathway for insertion into the endoplasmic reticulum. {ECO:0000269|PubMed:23048041}. |
| Mouse PG classification | HPG |
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