| Gene Information | |
|---|---|
| Gene Name | CDK9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 372 |
| Protein Names | Cyclin-dependent kinase 9 (EC 2.7.11.22) (EC 2.7.11.23) (C-2K) (Cell division cycle 2-like protein kinase 4) (Cell division protein kinase 9) (Serine/threonine-protein kinase PITALRE) (Tat-associated kinase complex catalytic subunit) |
| Target Name | cyclin-dependent kinase 9 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000136807 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P50750 |
| Gene Card | CDK9 |
| Uniprot ID | P50750 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.954409404) |
| Ortholog in Animals | Alpaca_ CDK9 ( ortholog_one2one ) Dog_ CDK9 ( ortholog_one2one ) Macaque_ CDK9 ( ortholog_one2one ) Mouse_ Cdk9 ( ortholog_one2one ) Pig_ CDK9 ( ortholog_one2one ) Rat_ Cdk9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDK14, CDKL2, CDK5, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | 0.007523(Chimpanzee);0.014112(Mouse);0.002159(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3BLH (X-ray 2.48A ) 3BLQ (X-ray 2.90A ) 3BLR (X-ray 2.80A ) 3LQ5 (X-ray 3.00A ) 3MI9 (X-ray 2.10A ) 3MIA (X-ray 3.00A ) 3MY1 (X-ray 2.80A ) 3TN8 (X-ray 2.95A ) 3TNH (X-ray 3.20A ) 3TNI (X-ray 3.23A ) 4BCF (X-ray 3.01A ) 4BCG (X-ray 3.08A ) 4BCH (X-ray 2.96A ) 4BCI (X-ray 3.10A ) 4BCJ (X-ray 3.16A ) 4EC8 (X-ray 3.60A ) 4EC9 (X-ray 3.21A ) 4IMY (X-ray 2.94A ) 4OGR (X-ray 3.00A ) 4OR5 (X-ray 2.90A ) 5L1Z (X-ray 5.90A ) 6CYT (X-ray 3.50A ) 6GZH (X-ray 3.17A ) 6W9E (X-ray 3.10A ) 6Z45 (X-ray 3.37A ) 7NWK (X-ray 2.81A ) |
| DBSNP | rs55640715 rs767418586 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Nucleus, PML body. Note=Accumulates on chromatin in response to replication stress. Complexed with CCNT1 in nuclear speckles, but uncomplexed form in the cytoplasm. The translocation from nucleus to cytoplasm is XPO1/CRM1-dependent. Associates with PML body when acetylated. |
| Mouse PG classification | NA |
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