| Gene Information | |
|---|---|
| Gene Name | CDK8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Cyclin-dependent kinase 8 (EC 2.7.11.22) (EC 2.7.11.23) (Cell division protein kinase 8) (Mediator complex subunit CDK8) (Mediator of RNA polymerase II transcription subunit CDK8) (Protein kinase K35) |
| Target Name | cyclin-dependent kinase 8 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000132964 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49336 |
| Gene Card | CDK8 |
| Uniprot ID | P49336 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.897160675) |
| Ortholog in Animals | Alpaca_ CDK8 ( ortholog_one2one ) Dog_ CDK8 ( ortholog_one2one ) GuineaPig_ CDK8 ( ortholog_one2one ) Macaque_ CDK8 ( ortholog_one2one ) Mouse_ Cdk8 ( ortholog_one2one ) Pig_ CDK8 ( ortholog_one2one ) Rat_ AABR07035338.1 ( ortholog_one2one ) Rabbit_ CDK8 ( ortholog_one2one ) |
| Ohnologs | CDK19 |
| Paralogs | CDK14, CDKL2, CDK5, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.049197(Chimpanzee);0.134530(Mouse);NULL(Rat);0.138525(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 3RGF (X-ray 2.20A ) 4CRL (X-ray 2.40A ) 4F6S (X-ray 2.60A ) 4F6U (X-ray 2.10A ) 4F6W (X-ray 2.39A ) 4F70 (X-ray 3.00A ) 4F7J (X-ray 2.60A ) 4F7L (X-ray 2.90A ) 4F7N (X-ray 2.65A ) 4F7S (X-ray 2.20A ) 4G6L (X-ray 2.70A ) 5BNJ (X-ray 2.64A ) 5CEI (X-ray 2.24A ) 5FGK (X-ray 2.36A ) 5HBE (X-ray 2.38A ) 5HBH (X-ray 2.50A ) 5HBJ (X-ray 3.00A ) 5HNB (X-ray 2.35A ) 5HVY (X-ray 2.39A ) 5I5Z (X-ray 2.60A ) 5ICP (X-ray 2.18A ) 5IDN (X-ray 2.26A ) 5IDP (X-ray 2.65A ) 5XQX (X-ray 2.30A ) 5XS2 (X-ray 2.04A ) 6QTG (X-ray 2.70A ) 6QTJ (X-ray 2.48A ) 6R3S (X-ray 2.19A ) 6T41 (X-ray 2.45A ) 6TPA (X-ray 2.80A ) 6Y0A (X-ray 2.19A ) |
| DBSNP | rs1593218885 rs1593218890 rs1565977796 rs1418353379 rs1593310364 |
| Subcellular location [CC] | Nucleus {ECO:0000305}. |
| Mouse PG classification | NA |
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