Gene Information
Gene NameCDK7
OrganismHomo sapiens (Human)
Gene Length346
Protein NamesCyclin-dependent kinase 7 (EC 2.7.11.22) (EC 2.7.11.23) (39 kDa protein kinase) (p39 Mo15) (CDK-activating kinase 1) (Cell division protein kinase 7) (Serine/threonine-protein kinase 1) (TFIIH basal transcription factor complex kinase subunit)
Target Namecyclin-dependent kinase 7
Target TypeClinical trial target
Gene Age1714 ( ENSG00000134058 )
3 ( ENSG00000277273 )
Evolutionary StageEukaryota
AlphaFoldDBP50613
Gene CardCDK7
Uniprot IDP50613
PfamPF00069
In ASDno
Allosteric Predictionyes (0.299516437)
Ortholog in AnimalsAlpaca_ CDK7 ( ortholog_one2one )
Dog_ CDK7 ( ortholog_one2one )
GuineaPig_ CDK7 ( ortholog_one2one )
Macaque_ CDK7 ( ortholog_one2one )
Mouse_ Cdk7 ( ortholog_one2one )
Pig_ CDK7 ( ortholog_one2one )
Rat_ Cdk7 ( ortholog_one2one )
Rabbit_ CDK7 ( ortholog_one2one )
OhnologsNA
ParalogsCDK14, CDKL2, CDK5, CDKL3, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B
TissueNA
Tissue SpecificityUbiquitous.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.251518(Rat);0.096116(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1UA2  (X-ray  3.02A  )  6O9L  (EM  7.20A  )  6XBZ  (EM  2.80A  )  6XD3  (EM  3.30A  )  7B5O  (EM  2.50A  )  7B5Q  (EM  2.50A  )  7EGB  (EM  3.30A  )  7EGC  (EM  3.90A  )  7ENA  (EM  4.07A  )  7ENC  (EM  4.13A  )  7LBM  (EM  4.80A  )  7NVR  (EM  4.50A  ) 
DBSNP rs34584424 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:10958787, ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}. Cytoplasm {ECO:0000269|PubMed:15695176}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:19071173}. Note=Colocalizes with PRKCI in the cytoplasm and nucleus (PubMed:15695176). Translocates from the nucleus to cytoplasm and perinuclear region in response to DNA-bound peptides (PubMed:19071173). {ECO:0000269|PubMed:15695176, ECO:0000269|PubMed:19071173}.
Mouse PG classificationNA
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