| Gene Information | |
|---|---|
| Gene Name | CDK5R1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 307 |
| Protein Names | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] |
| Target Name | cyclin-dependent kinase 5 activator 1 |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000176749 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15078 |
| Gene Card | CDK5R1 |
| Uniprot ID | Q15078 |
| Pfam | PF03261 |
| In ASD | no |
| Allosteric Prediction | yes (0.135653122) |
| Ortholog in Animals | Alpaca_ CDK5R1 ( ortholog_one2one ) Dog_ CDK5R1 ( ortholog_one2one ) GuineaPig_ CDK5R1 ( ortholog_one2one ) Macaque_ CDK5R1 ( ortholog_one2one ) Mouse_ Cdk5r1 ( ortholog_one2one ) Pig_ CDK5R1 ( ortholog_one2one ) Rat_ Cdk5r1 ( ortholog_one2one ) |
| Ohnologs | CDK5R2 |
| Paralogs | CDK5R2 |
| Tissue | brain, cerebral.cortex, spleen |
| Tissue Specificity | Brain and neuron specific. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1H4L (X-ray 2.65A ) 1UNG (X-ray 2.30A ) 1UNH (X-ray 2.35A ) 1UNL (X-ray 2.20A ) 3O0G (X-ray 1.95A ) 6LDP (X-ray 2.35A ) 7CNG (X-ray 3.49A ) 7VDP (X-ray 2.09A ) 7VDQ (X-ray 2.91A ) 7VDR (X-ray 2.55A ) 7VDS (X-ray 3.05A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Cyclin-dependent kinase 5 activator 1, p35]: Cell membrane {ECO:0000305|PubMed:17671990}; Lipid-anchor {ECO:0000269|PubMed:18507738}; Cytoplasmic side {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:10604467}. Note=In the primary cortical neurons, p35 is present in the peripheries and nerve terminals. {ECO:0000269|PubMed:10604467}.; [Cyclin-dependent kinase 5 activator 1, p25]: Nucleus {ECO:0000269|PubMed:18507738}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10604467}. Perikaryon {ECO:0000269|PubMed:10604467}. Note=The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions (PubMed:18507738). In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites (PubMed:18507738). {ECO:0000269|PubMed:18507738}. |
| Mouse PG classification | NA |
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