| Gene Information | |
|---|---|
| Gene Name | CDK5 |
| Organism | Homo sapiens (Human) |
| Gene Length | 292 |
| Protein Names | Cyclin-dependent kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Cyclin-dependent-like kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) |
| Target Name | cyclin-dependent kinase 5 |
| Target Type | Patented-recorded target |
| Gene Age | 168 ( ENSG00000164885 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q00535 |
| Gene Card | CDK5 |
| Uniprot ID | Q00535 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (0.996666457) |
| Ortholog in Animals | Alpaca_ CDK5 ( ortholog_one2one ) Dog_ CDK5 ( ortholog_one2one ) GuineaPig_ CDK5 ( ortholog_one2one ) Macaque_ CDK5 ( ortholog_one2one ) Mouse_ Cdk5 ( ortholog_one2one ) Rat_ Cdk5 ( ortholog_one2one ) Rabbit_ CDK5 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDK14, CDKL2, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDK4, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Ubiquitously expressed (PubMed:17009320, PubMed:19693690). Accumulates in cortical neurons (at protein level) (PubMed:17009320). {ECO:0000269|PubMed:17009320, ECO:0000269|PubMed:19693690}.; [Isoform 2]: Expressed in the testis, skeletal muscle, colon, bone marrow and ovary. {ECO:0000269|PubMed:19693690}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002101(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1H4L (X-ray 2.65A ) 1UNG (X-ray 2.30A ) 1UNH (X-ray 2.35A ) 1UNL (X-ray 2.20A ) 3O0G (X-ray 1.95A ) 4AU8 (X-ray 1.90A ) 7VDP (X-ray 2.09A ) 7VDQ (X-ray 2.91A ) 7VDR (X-ray 2.55A ) 7VDS (X-ray 3.05A ) |
| DBSNP | rs35186917 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12691662}. Nucleus {ECO:0000269|PubMed:12691662}. Cell membrane {ECO:0000269|PubMed:17009320}; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P49615}. Cell projection, growth cone {ECO:0000250|UniProtKB:P49615}. Postsynaptic density {ECO:0000250|UniProtKB:Q03114}. Synapse {ECO:0000250|UniProtKB:Q03114}. Note=In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5. {ECO:0000250}.; [Isoform 2]: Nucleus. |
| Mouse PG classification | NA |
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