| Gene Information | |
|---|---|
| Gene Name | CDK4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 303 |
| Protein Names | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) |
| Target Name | cyclin-dependent kinase 4 |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000135446 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P11802 |
| Gene Card | CDK4 |
| Uniprot ID | P11802 |
| Pfam | PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.26776379) |
| Ortholog in Animals | Alpaca_ CDK4 ( ortholog_one2one ) Dog_ CDK4 ( ortholog_one2many ) GuineaPig_ CDK4 ( ortholog_one2one ) Macaque_ CDK4 ( ortholog_one2one ) Mouse_ Cdk4 ( ortholog_one2one ) Pig_ CDK4 ( ortholog_one2one ) Rat_ Cdk4 ( ortholog_one2one ) Rabbit_ CDK4 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CDK14, CDKL2, CDK5, CDKL3, CDK7, CDK3, CDK1, CDKL1, CDK19, CDKL5, CDK6, CDK16, CDK15, CDKL4, CDK2, CDK20, CDK9, CDK12, CDK8, CDK10, CDK11B, CDK11A, CDK13, CDK18, CDK17, PRPF4B |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.035088(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 2W96 (X-ray 2.30A ) 2W99 (X-ray 2.80A ) 2W9F (X-ray 2.85A ) 2W9Z (X-ray 2.45A ) 3G33 (X-ray 3.00A ) 5FWK (EM 3.90A ) 5FWL (EM 9.00A ) 5FWM (EM 8.00A ) 5FWP (EM 7.20A ) 6P8E (X-ray 2.30A ) 6P8F (X-ray 2.89A ) 6P8G (X-ray 2.80A ) 6P8H (X-ray 3.19A ) |
| DBSNP | rs11547328 rs104894340 rs144890720 rs3211612 rs34386532 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18827403}. Nucleus {ECO:0000269|PubMed:18827403, ECO:0000269|PubMed:20399237, ECO:0000269|PubMed:9106657}. Nucleus membrane {ECO:0000269|PubMed:18827403}. Note=Cytoplasmic when non-complexed. Forms a cyclin D-CDK4 complex in the cytoplasm as cells progress through G(1) phase. The complex accumulates on the nuclear membrane and enters the nucleus on transition from G(1) to S phase. Also present in nucleoli and heterochromatin lumps. Colocalizes with RB1 after release into the nucleus. {ECO:0000269|PubMed:18827403}. |
| Mouse PG classification | LPG |
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