| Gene Information | |
|---|---|
| Gene Name | COL4A2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1712 |
| Protein Names | Collagen alpha-2(IV) chain [Cleaved into: Canstatin] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134871 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P08572 |
| Gene Card | COL4A2 |
| Uniprot ID | P08572 |
| Pfam | PF01413; PF01391 |
| In ASD | no |
| Allosteric Prediction | no (-0.691230206) |
| Ortholog in Animals | Alpaca_ COL4A2 ( ortholog_one2one ) Dog_ COL4A2 ( ortholog_one2one ) GuineaPig_ COL4A2 ( ortholog_one2one ) Macaque_ COL4A2 ( ortholog_one2one ) Mouse_ Col4a2 ( ortholog_one2one ) Pig_ COL4A2 ( ortholog_one2one ) Rat_ Col4a2 ( ortholog_one2one ) Rabbit_ COL4A2 ( ortholog_one2one ) |
| Ohnologs | COL4A5, COL4A6, COL4A3 |
| Paralogs | COL9A2, COLQ, COL4A1, COL17A1, COL1A1, EDA, COL22A1, COL11A1, COL15A1, COL9A3, COL26A1, COL13A1, COL7A1, COL16A1, COL5A1, COL25A1, COL3A1, COL6A2, COL5A3, COL27A1, COL1A2, COL24A1, COL5A2, COL18A1, COL9A1, COL23A1, COL2A1, COL20A1, COL4A4, COL4A6, COL28A1, COL11A2, COL21A1, COL6A1, EMID1, COL4A5, COL4A3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.027573(Mouse);0.001823(Rat);0.016667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1LI1 (X-ray 1.90A ) 5NAX (X-ray 2.82A ) 5NB2 (X-ray 2.50A ) 6MPX (X-ray 1.90A ) |
| DBSNP | rs62621885 rs7990383 rs3803230 rs78829338 rs9583500 rs387906603 rs184812559 rs117412802 rs62621875 rs387906602 rs45520539 rs201105747 |
| Subcellular location [CC] | Secreted, extracellular space, extracellular matrix, basement membrane. |
| Mouse PG classification | LPG |
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