Gene Information
Gene NameDIXDC1
OrganismHomo sapiens (Human)
Gene Length683
Protein NamesDixin (Coiled-coil protein DIX1) (Coiled-coil-DIX1) (DIX domain-containing protein 1)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000150764 )
Evolutionary StageEumetazoa
AlphaFoldDBQ155Q3
Gene CardDIXDC1
Uniprot IDQ155Q3
PfamPF00307; PF00778
In ASDno
Allosteric Predictionno (-0.626119703)
Ortholog in AnimalsAlpaca_ DIXDC1 ( ortholog_one2one )
Dog_ DIXDC1 ( ortholog_one2one )
GuineaPig_ DIXDC1 ( ortholog_one2one )
Macaque_ DIXDC1 ( ortholog_one2one )
Mouse_ Dixdc1 ( ortholog_one2one )
Rat_ Dixdc1 ( ortholog_one2one )
Rabbit_ DIXDC1 ( ortholog_one2one )
OhnologsNA
ParalogsDVL2, DVL1, DVL3
TissueNA
Tissue SpecificityUbiquitously expressed with higher expression in cardiac and skeletal muscles. {ECO:0000269|PubMed:16814745}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 3PZ7  (X-ray  2.44A 
DBSNP rs34575249 
Subcellular location [CC]Cell junction, focal adhesion {ECO:0000269|PubMed:16814745}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:16814745}. Cytoplasm {ECO:0000269|PubMed:20085589}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis (PubMed:19375513). Associated with actin stress fiber at the filament ends (PubMed:16814745). {ECO:0000269|PubMed:16814745, ECO:0000269|PubMed:19375513}.;
[Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16814745}. Note=Not associated with stress fibers. {ECO:0000269|PubMed:16814745}.
Mouse PG classificationNA
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