| Gene Information | |
|---|---|
| Gene Name | PPS |
| Organism | Homo sapiens (Human) |
| Gene Length | 448 |
| Protein Names | Inositol polyphosphate 5-phosphatase K (EC 3.1.3.56) (Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase) (EC 3.1.3.86) (Phosphatidylinositol-4,5-bisphosphate 5-phosphatase) (EC 3.1.3.36) (Skeletal muscle and kidney-enriched inositol phosphatase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9BT40 |
| Gene Card | INPP5K |
| Uniprot ID | Q9BT40 |
| Pfam | PF03372; PF17751 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed with highest levels in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:10753883}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs750781027 rs1060505038 rs1060505039 rs749383757 rs761612652 rs766046008 rs993849342 |
| Subcellular location [CC] | Endoplasmic reticulum {ECO:0000269|PubMed:12536145, ECO:0000269|PubMed:26940976, ECO:0000269|PubMed:28190456}. Cytoplasm {ECO:0000269|PubMed:10753883}. Note=Following stimulation with EGF, translocates to membrane ruffles (PubMed:12536145, PubMed:26940976). Concentrated at the periphery of the nucleus (PubMed:10753883). {ECO:0000269|PubMed:10753883, ECO:0000269|PubMed:12536145, ECO:0000269|PubMed:26940976}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |