| Gene Information | |
|---|---|
| Gene Name | CDHF8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 4349 |
| Protein Names | Protocadherin Fat 2 (hFat2) (Cadherin family member 8) (Multiple epidermal growth factor-like domains protein 1) (Multiple EGF-like domains protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | NA |
| Gene Card | FAT2 |
| Uniprot ID | Q9NYQ8 |
| Pfam | PF00028; PF00008; PF02210 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in epidermal keratinocytes, infant brain, cerebellum, and also in a variety of tumors, such as pancreatic cancer, diffuse type gastric cancer, ovarian cancer, esophageal cancer, skin squamous cell carcinoma, head and neck cancer. Not expressed in melanoma cell line A375 cells, normal epidermal melanocytes or normal dermal fibroblasts. Expressed in epidermal keratinocytes and squamous cell carcinoma (at protein level). {ECO:0000269|PubMed:16865240, ECO:0000269|PubMed:17900869}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs11739693 rs3734061 rs1432862 rs9324700 rs3734056 rs3734055 rs2304053 rs6872614 rs35640822 rs2278371 rs2278370 rs10044879 rs34464977 rs34493925 rs6892335 rs3734053 rs7718054 rs2304024 rs2053028 rs770597316 rs6650971 rs201335279 rs35963695 rs2304029 rs1105168 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000269|PubMed:17900869}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O88277}. Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. {ECO:0000269|PubMed:17900869}. |
| Mouse PG classification | NA |
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