Gene Information
Gene NameSCN3A
OrganismHomo sapiens (Human)
Gene Length2000
Protein NamesSodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3)
Target Namevoltage-gated sodium channel alpha nav1.3
Target TypeSuccessful target
Gene Age424 ( ENSG00000153253 )
Evolutionary StageMammalia
AlphaFoldDBQ9NY46
Gene CardSCN3A
Uniprot IDQ9NY46
PfamPF00520; PF06512; PF11933
In ASDno
Allosteric Predictionyes (0.606754909)
Ortholog in AnimalsAlpaca_ SCN3A ( ortholog_one2one )
Dog_ SCN3A ( ortholog_one2one )
GuineaPig_ SCN3A ( ortholog_one2one )
Macaque_ SCN3A ( ortholog_one2one )
Mouse_ Scn3a ( ortholog_one2one )
Pig_ SCN3A ( ortholog_one2one )
Rat_ Scn3a ( ortholog_one2one )
Rabbit_ SCN3A ( ortholog_one2one )
OhnologsSCN4A, SCN11A, SCN5A, SCN10A, SCN8A
ParalogsSCN11A, CACNA1C, CATSPER1, CACNA1E, CACNA1I, SCN9A, CACNA1B, SCN7A, SCN5A, SCN2A, SCN1A, CACNA1A, CACNA1F, CACNA1H, CATSPER2, CACNA1G, SCN8A, NALCN, CACNA1D, CATSPER4, SCN10A, CACNA1S, CATSPER3, TPCN1, TPCN2, SCN4A
Tissuebrain
Tissue SpecificityExpressed in enterochromaffin cells in both colon and small bowel (at protein level). {ECO:0000269|PubMed:29142310}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7W77  (EM  3.30A  )  7W7F  (EM  3.35A  ) 
DBSNP rs774195502  rs755440336  rs1057518801  rs140990288  rs12474273  rs377632429  rs1057520753  rs758906955  rs1312429782  rs1553517274  rs1170839078  rs3731762 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:28235671};
Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}.
Mouse PG classificationNA
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