| Gene Information | |
|---|---|
| Gene Name | CDH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 906 |
| Protein Names | Cadherin-2 (CDw325) (Neural cadherin) (N-cadherin) (CD antigen CD325) |
| Target Name | neural cadherin |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000170558 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P19022 |
| Gene Card | CDH2 |
| Uniprot ID | P19022 |
| Pfam | PF01049; PF00028; PF08758 |
| In ASD | no |
| Allosteric Prediction | yes (0.442667803) |
| Ortholog in Animals | Alpaca_ CDH2 ( ortholog_one2one ) Dog_ CDH2 ( ortholog_one2one ) GuineaPig_ CDH2 ( ortholog_one2one ) Macaque_ CDH2 ( ortholog_one2one ) Mouse_ Cdh2 ( ortholog_one2one ) Pig_ CDH2 ( ortholog_one2one ) Rat_ Cdh2 ( ortholog_one2one ) Rabbit_ CDH2 ( ortholog_one2one ) |
| Ohnologs | CDH26, CDH22, CDH4, CDH1, CDH3, CDH19, CDH7, CDH20, CDH15, CDH11, CDH13, CDH8, CDH5 |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDH1, CDHR2, CDH22, CDH5 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.013613(Mouse);0.253028(Rat);0.020000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17495042 rs17445840 rs1041970 rs1041972 rs1599017933 rs568089577 rs17857112 rs1599011050 rs1599011050 rs201775968 rs754880999 rs1599010918 rs199984052 rs2289664 |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P15116}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P15116}. Cell junction {ECO:0000269|PubMed:28169360}. Cell surface {ECO:0000250|UniProtKB:P15116}. Cell junction, desmosome {ECO:0000250|UniProtKB:P15116}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P15116}. Note=Colocalizes with TMEM65 at the intercalated disk in cardiomyocytes. Colocalizes with OBSCN at the intercalated disk and at sarcolemma in cardiomyocytes. {ECO:0000250|UniProtKB:P15116}. |
| Mouse PG classification | NA |
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