| Gene Information | |
|---|---|
| Gene Name | CDH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 882 |
| Protein Names | Cadherin-1 (CAM 120/80) (Epithelial cadherin) (E-cadherin) (Uvomorulin) (CD antigen CD324) [Cleaved into: E-Cad/CTF1; E-Cad/CTF2; E-Cad/CTF3] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000039068 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P12830 |
| Gene Card | CDH1 |
| Uniprot ID | P12830 |
| Pfam | PF01049; PF00028; PF08758 |
| In ASD | no |
| Allosteric Prediction | yes (1.054659742) |
| Ortholog in Animals | Alpaca_ CDH1 ( ortholog_one2one ) Dog_ CDH1 ( ortholog_one2one ) GuineaPig_ CDH1 ( ortholog_one2one ) Macaque_ CDH1 ( ortholog_one2one ) Mouse_ Cdh1 ( ortholog_one2one ) Pig_ CDH1 ( ortholog_one2one ) Rat_ Cdh1 ( ortholog_one2one ) Rabbit_ CDH1 ( ortholog_one2one ) |
| Ohnologs | CDH19, CDH7, CDH20, CDH26, CDH15, CDH13, CDH22, CDH2, CDH4, CDH10, CDH9, CDH6, CDH24, CDH18, CDH12 |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDHR2, CDH22, CDH5, CDH2 |
| Tissue | NA |
| Tissue Specificity | Non-neural epithelial tissues. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001657(Rat);0.066532(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1O6S (X-ray 1.80A ) 2O72 (X-ray 2.00A ) 2OMT (X-ray 2.00A ) 2OMU (X-ray 1.80A ) 2OMV (X-ray 1.90A ) 2OMX (X-ray 1.70A ) 2OMY (X-ray 1.70A ) 2OMZ (X-ray 1.60A ) 3FF7 (X-ray 1.80A ) 3FF8 (X-ray 2.00A ) 3L6X (X-ray 2.40A ) 3L6Y (X-ray 3.00A ) 4ZT1 (X-ray 1.92A ) 4ZTE (X-ray 2.13A ) 6CXY (X-ray 2.20A ) 6OLE (EM 3.10A ) 6OLF (EM 3.90A ) 6OLG (EM 3.40A ) 6VEL (X-ray 2.65A ) 7STZ (X-ray 2.95A ) |
| DBSNP | rs35606263 rs1064794231 rs1555515445 rs587776399 rs200932258 rs267606712 rs116093741 rs34466743 rs370864592 rs36087757 rs35520415 rs35187787 rs780759537 rs33935154 rs2276331 rs121964878 rs9282655 rs121964871 rs372989292 rs35572355 rs121964872 rs34507583 |
| Subcellular location [CC] | Cell junction, adherens junction {ECO:0000269|PubMed:28169360}. Cell membrane {ECO:0000269|PubMed:19403558, ECO:0000269|PubMed:28301459}; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma-catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. |
| Mouse PG classification | LPG |
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