| Gene Information | |
|---|---|
| Gene Name | CDH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 496 |
| Protein Names | Fizzy-related protein homolog (Fzr) (CDC20-like protein 1) (Cdh1/Hct1 homolog) (hCDH1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000039068 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9UM11 |
| Gene Card | FZR1 |
| Uniprot ID | Q9UM11 |
| Pfam | PF12894; PF00400 |
| In ASD | no |
| Allosteric Prediction | yes (1.054659742) |
| Ortholog in Animals | Alpaca_ CDH1 ( ortholog_one2one ) Dog_ CDH1 ( ortholog_one2one ) GuineaPig_ CDH1 ( ortholog_one2one ) Macaque_ CDH1 ( ortholog_one2one ) Mouse_ Cdh1 ( ortholog_one2one ) Pig_ CDH1 ( ortholog_one2one ) Rat_ Cdh1 ( ortholog_one2one ) Rabbit_ CDH1 ( ortholog_one2one ) |
| Ohnologs | CDH19, CDH7, CDH20, CDH26, CDH15, CDH13, CDH22, CDH2, CDH4, CDH10, CDH9, CDH6, CDH24, CDH18, CDH12 |
| Paralogs | CDH7, CDH9, CDH20, CDH4, CDH18, PCDH1, PCDH20, CDH26, CDH19, PCDH9, CDH3, PCDH11Y, PCDH11X, CDH17, CDHR5, CDHR3, DCHS2, CDH24, CDH23, PCDH7, CDH15, CDHR1, DCHS1, CDH11, CDH8, CDH10, CDH12, CDH13, CDH6, CDHR2, CDH22, CDH5, CDH2 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed at high levels in heart, liver, spleen and some cancer cell lines whereas isoform 3 is expressed only at low levels in these tissues. {ECO:0000269|PubMed:12797865}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.357920(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4UI9 (EM 3.60A ) 5L9T (EM 6.40A ) 5L9U (EM 6.40A ) 7QE7 (EM 2.90A ) |
| DBSNP | NA |
| Subcellular location [CC] | [Isoform 2]: Nucleus.; [Isoform 3]: Cytoplasm. |
| Mouse PG classification | LPG |
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