Gene Information
Gene NameCNGA1
OrganismHomo sapiens (Human)
Gene Length686
Protein NamescGMP-gated cation channel alpha-1 (Cyclic nucleotide-gated cation channel 1) (Cyclic nucleotide-gated channel alpha-1) (CNG channel alpha-1) (CNG-1) (CNG1) (Cyclic nucleotide-gated channel, photoreceptor) (Rod photoreceptor cGMP-gated channel subunit alpha)
Target Namecyclic nucleotide-gated channel alpha-1
Target TypeClinical trial target
Gene Age987 ( ENSG00000198515 )
Evolutionary StageEukaryota
AlphaFoldDBP29973
Gene CardCNGA1
Uniprot IDP29973
PfamPF16526; PF00027; PF00520
In ASDno
Allosteric Predictionyes (0.250898505)
Ortholog in AnimalsAlpaca_ CNGA1 ( ortholog_one2one )
Alpaca_ CNGA1 ( ortholog_one2many )
Dog_ CNGA1 ( ortholog_one2one )
GuineaPig_ CNGA1 ( ortholog_one2one )
Macaque_ CNGA1 ( ortholog_one2one )
Mouse_ Cnga1 ( ortholog_one2one )
Pig_ CNGA1 ( ortholog_one2one )
Rat_ Cnga1 ( ortholog_one2one )
Rabbit_ CNGA1 ( ortholog_one2one )
OhnologsCNGA4, CNGA2, CNGA3
ParalogsKCNH7, KCNH1, HCN3, CNGA3, KCNH3, HCN4, HCN2, KCNH8, HCN1, CNGB3, CNGB1, KCNH6, KCNH2, KCNH4, CNGA2, CNGA4, KCNH5
TissueNA
Tissue SpecificityRod cells in the retina.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.004323(Rat);0.066667(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 7LFT  (EM  2.60A  )  7LFW  (EM  2.90A  )  7LFX  (EM  3.10A  )  7LFY  (EM  3.60A  )  7LG1  (EM  2.70A  )  7RH9  (EM  2.61A  )  7RHG  (EM  2.88A  )  7RHH  (EM  3.31A  )  7RHI  (EM  3.31A  )  7RHJ  (EM  2.88A  )  7RHK  (EM  3.27A  )  7RHL  (EM  3.03A  ) 
DBSNP rs76537883  rs28642966  rs28642966  rs62625014 
Subcellular location [CC]Cell membrane {ECO:0000250|UniProtKB:Q00194};
Multi-pass membrane protein {ECO:0000250|UniProtKB:Q00194}.
Mouse PG classificationNA
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