| Gene Information | |
|---|---|
| Gene Name | CDCA8 |
| Organism | Homo sapiens (Human) |
| Gene Length | 280 |
| Protein Names | Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000134690 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q53HL2 |
| Gene Card | CDCA8 |
| Uniprot ID | Q53HL2 |
| Pfam | PF10512; PF10444 |
| In ASD | no |
| Allosteric Prediction | no (-0.102660516) |
| Ortholog in Animals | Alpaca_ CDCA8 ( ortholog_one2one ) Dog_ CDCA8 ( ortholog_one2one ) GuineaPig_ CDCA8 ( ortholog_one2one ) Macaque_ CDCA8 ( ortholog_one2one ) Mouse_ Cdca8 ( ortholog_one2one ) Pig_ CDCA8 ( ortholog_one2one ) Rat_ Cdca8 ( ortholog_one2one ) Rabbit_ CDCA8 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | colon, testis, brain |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001759(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2KDD (NMR - ) 2QFA (X-ray 1.40A ) 2RAW (X-ray 2.40A ) 2RAX (X-ray 3.30A ) 6YIE (X-ray 3.49A ) 6YIF (X-ray 1.81A ) 6YIH (X-ray 2.55A ) |
| DBSNP | rs17851453 |
| Subcellular location [CC] | Nucleus, nucleolus {ECO:0000269|PubMed:18946085}. Cytoplasm {ECO:0000269|PubMed:18946085}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15561729}. Chromosome, centromere {ECO:0000269|PubMed:20739936}. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. {ECO:0000269|PubMed:18946085}. |
| Mouse PG classification | NA |
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