| Gene Information | |
|---|---|
| Gene Name | PIN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 163 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase Pin1) (PPIase Pin1) (Rotamase Pin1) |
| Target Name | peptidyl-prolyl cis-trans isomerase nima-interacting 1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000127445 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13526 |
| Gene Card | PIN1 |
| Uniprot ID | Q13526 |
| Pfam | PF00639; PF00397 |
| In ASD | yes |
| Allosteric Prediction | yes (0.946814613) |
| Ortholog in Animals | Alpaca_ PIN1 ( ortholog_one2one ) Dog_ PIN1 ( ortholog_one2one ) GuineaPig_ PIN1 ( ortholog_one2one ) Macaque_ PIN1 ( ortholog_one2one ) Mouse_ Pin1rt1 ( ortholog_one2many ) Mouse_ Pin1 ( ortholog_one2many ) Pig_ PIN1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PIN4 |
| Tissue | NA |
| Tissue Specificity | Expressed in immune cells in the lung (at protein level) (PubMed:29686383). The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO:0000269|PubMed:17828269, ECO:0000269|PubMed:21497122, ECO:0000269|PubMed:29686383}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F8A (X-ray 1.84A ) 1I6C (NMR - ) 1I8G (NMR - ) 1I8H (NMR - ) 1NMV (NMR - ) 1NMW (NMR - ) 1PIN (X-ray 1.35A ) 1ZCN (X-ray 1.90A ) 2F21 (X-ray 1.50A ) 2ITK (X-ray 1.45A ) 2KBU (NMR - ) 2KCF (NMR - ) 2LB3 (NMR - ) 2M8I (NMR - ) 2M8J (NMR - ) 2M9E (NMR - ) 2M9F (NMR - ) 2M9I (NMR - ) 2M9J (NMR - ) 2N1O (NMR - ) 2Q5A (X-ray 1.50A ) 2RUC (NMR - ) 2RUD (NMR - ) 2RUQ (NMR - ) 2RUR (NMR - ) 2XP3 (X-ray 2.00A ) 2XP4 (X-ray 1.80A ) 2XP5 (X-ray 1.90A ) 2XP6 (X-ray 1.90A ) 2XP7 (X-ray 2.00A ) 2XP8 (X-ray 2.10A ) 2XP9 (X-ray 1.90A ) 2XPA (X-ray 1.90A ) 2XPB (X-ray 2.00A ) 2ZQS (X-ray 1.90A ) 2ZQT (X-ray 1.46A ) 2ZQU (X-ray 2.50A ) 2ZQV (X-ray 2.50A ) 2ZR4 (X-ray 2.00A ) 2ZR5 (X-ray 2.60A ) 2ZR6 (X-ray 3.20A ) 3I6C (X-ray 1.30A ) 3IK8 (X-ray 1.85A ) 3IKD (X-ray 2.00A ) 3IKG (X-ray 1.86A ) 3JYJ (X-ray 1.87A ) 3KAB (X-ray 2.19A ) 3KAC (X-ray 2.00A ) 3KAD (X-ray 1.95A ) 3KAF (X-ray 2.30A ) 3KAG (X-ray 1.90A ) 3KAH (X-ray 2.30A ) 3KAI (X-ray 1.90A ) 3KCE (X-ray 1.90A ) 3NTP (X-ray 1.76A ) 3ODK (X-ray 2.30A ) 3OOB (X-ray 1.89A ) 3TC5 (X-ray 1.40A ) 3TCZ (X-ray 2.10A ) 3TDB (X-ray 2.27A ) 3WH0 (X-ray 1.60A ) 4GWT (X-ray 2.25A ) 4GWV (X-ray 3.05A ) 4QIB (X-ray 1.86A ) 4TNS (X-ray 1.33A ) 4TYO (X-ray 1.75A ) 4U84 (X-ray 1.78A ) 4U85 (X-ray 1.70A ) 4U86 (X-ray 1.60A ) 5B3W (X-ray 2.40A ) 5B3X (X-ray 2.40A ) 5B3Y (X-ray 1.90A ) 5B3Z (X-ray 2.30A ) 5BMY (X-ray 2.00A ) 5GPH (NMR - ) 5UY9 (X-ray 1.85A ) 5VTI (X-ray 1.80A ) 5VTJ (X-ray 1.50A ) 5VTK (X-ray 1.99A ) 6DUN (X-ray 1.59A ) 6O33 (X-ray 1.74A ) 6O34 (X-ray 1.57A ) 6SVC (NMR - ) 6SVE (NMR - ) 6SVH (NMR - ) 6VAJ (X-ray 1.42A ) 7AOG (X-ray 1.50A ) 7AXN (X-ray 1.40A ) 7AYF (X-ray 1.75A ) 7AZ1 (X-ray 1.15A ) 7AZ2 (X-ray 1.08A ) 7BDP (X-ray 1.75A ) 7BDT (X-ray 1.75A ) 7BDY (X-ray 1.80A ) 7BFW (X-ray 1.80A ) 7BG3 (X-ray 1.40A ) 7BGQ (X-ray 1.75A ) 7BGR (X-ray 1.80A ) 7BGV (X-ray 1.68A ) 7BGW (X-ray 1.90A ) 7EFJ (X-ray 1.99A ) 7EFX (X-ray 2.41A ) 7EKV (X-ray 1.95A ) 7F0M (X-ray 1.90A ) 7NIF (X-ray 1.71A ) 7NIG (X-ray 1.90A ) 7NJ6 (X-ray 1.59A ) 7NJ8 (X-ray 1.80A ) 7NJA (X-ray 1.75A ) 7NRK (X-ray 1.75A ) 7NRL (X-ray 1.80A ) 7OQ9 (X-ray 1.80A ) 7OQA (X-ray 1.80A ) 7SA5 (NMR - ) 7SUQ (NMR - ) 7SUR (NMR - ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16476580, ECO:0000269|PubMed:23623683}. Nucleus speckle {ECO:0000269|PubMed:21497122}. Cytoplasm {ECO:0000269|PubMed:21497122}. Note=Colocalizes with NEK6 in the nucleus (PubMed:16476580). Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization (PubMed:21497122). {ECO:0000269|PubMed:16476580}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |