| Gene Information | |
|---|---|
| Gene Name | KCNN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | Small conductance calcium-activated potassium channel protein 2 (SK2) (SKCa 2) (SKCa2) (KCa2.2) |
| Target Name | calcium-activated potassium channel |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000080709 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9H2S1 |
| Gene Card | KCNN2 |
| Uniprot ID | Q9H2S1 |
| Pfam | PF02888; PF07885; PF03530 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999872004) |
| Ortholog in Animals | Alpaca_ KCNN2 ( ortholog_one2one ) Dog_ KCNN2 ( ortholog_one2one ) GuineaPig_ KCNN2 ( ortholog_one2one ) Macaque_ KCNN2 ( ortholog_one2one ) Mouse_ Kcnn2 ( ortholog_one2one ) Pig_ KCNN2 ( ortholog_one2one ) Rat_ Kcnn2 ( ortholog_one2one ) Rabbit_ KCNN2 ( ortholog_one2one ) |
| Ohnologs | KCNN1, KCNN3 |
| Paralogs | KCNN3, KCNN4, KCNN1 |
| Tissue | adrenal.gland |
| Tissue Specificity | Expressed in atrial myocytes (at protein level). Widely expressed. {ECO:0000269|PubMed:13679367}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 5V02 (X-ray 1.78A ) 5WBX (X-ray 1.90A ) 5WC5 (X-ray 2.30A ) 6ALE (X-ray 2.50A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. |
| Mouse PG classification | NA |
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