| Gene Information | |
|---|---|
| Gene Name | PLD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1074 |
| Protein Names | Phospholipase D1 (PLD 1) (hPLD1) (EC 3.1.4.4) (Choline phosphatase 1) (Phosphatidylcholine-hydrolyzing phospholipase D1) |
| Target Name | phospholipase d1 |
| Target Type | Patented-recorded target |
| Gene Age | 680 ( ENSG00000075651 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13393 |
| Gene Card | PLD1 |
| Uniprot ID | Q13393 |
| Pfam | PF00169; PF00614; PF13091; PF00787 |
| In ASD | no |
| Allosteric Prediction | yes (1.103953136) |
| Ortholog in Animals | Alpaca_ PLD1 ( ortholog_one2one ) Dog_ PLD1 ( ortholog_one2one ) GuineaPig_ PLD1 ( ortholog_one2one ) Macaque_ PLD1 ( ortholog_one2one ) Mouse_ Pld1 ( ortholog_one2one ) Pig_ PLD1 ( ortholog_one2one ) Rat_ Pld1 ( ortholog_one2one ) Rabbit_ PLD1 ( ortholog_one2one ) |
| Ohnologs | PLD2 |
| Paralogs | PLD2 |
| Tissue | NA |
| Tissue Specificity | Expressed abundantly in the pancreas and heart and at high levels in brain, placenta, spleen, uterus and small intestine. {ECO:0000269|PubMed:9582313}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6U8Z (X-ray 1.80A ) |
| DBSNP | rs9819927 rs769669104 rs2290480 rs2287579 rs9827333 |
| Subcellular location [CC] | Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Z280}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. Late endosome membrane {ECO:0000250|UniProtKB:Q9Z280}; Lipid-anchor {ECO:0000250|UniProtKB:Q9Z280}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z280}. |
| Mouse PG classification | NA |
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