| Gene Information | |
|---|---|
| Gene Name | CDC42 |
| Organism | Homo sapiens (Human) |
| Gene Length | 191 |
| Protein Names | Cell division control protein 42 homolog (EC 3.6.5.2) (G25K GTP-binding protein) |
| Target Name | cell division control protein 42 homolog |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000070831 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P60953 |
| Gene Card | CDC42 |
| Uniprot ID | P60953 |
| Pfam | PF00071 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000306656) |
| Ortholog in Animals | Alpaca_ CDC42 ( ortholog_one2one ) Dog_ CDC42 ( ortholog_one2many ) GuineaPig_ CDC42 ( ortholog_one2one ) Macaque_ CDC42 ( ortholog_one2one ) Mouse_ Cdc42 ( ortholog_one2one ) Pig_ CDC42 ( ortholog_one2one ) Rat_ Cdc42 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RND1, RHOT1, RHOBTB3, RHOT2, RAC1, RAC3, RHOJ, RHOA, RHOC, RHOB, RHOV, RHOQ, RHOBTB2, RND2, RND3, RHOD, RHOF, RHOG, RHOU, RAC2, RHOBTB1, RHOH |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.095605(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1A4R (X-ray 2.50A ) 1AJE (NMR - ) 1AM4 (X-ray 2.70A ) 1AN0 (X-ray 2.80A ) 1CEE (NMR - ) 1CF4 (NMR - ) 1DOA (X-ray 2.60A ) 1E0A (NMR - ) 1EES (NMR - ) 1GRN (X-ray 2.10A ) 1GZS (X-ray 2.30A ) 1KI1 (X-ray 2.30A ) 1KZ7 (X-ray 2.40A ) 1KZG (X-ray 2.60A ) 1NF3 (X-ray 2.10A ) 2ASE (NMR - ) 2DFK (X-ray 2.15A ) 2KB0 (NMR - ) 2NGR (X-ray 1.90A ) 2ODB (X-ray 2.40A ) 2QRZ (X-ray 2.40A ) 2WM9 (X-ray 2.20A ) 2WMN (X-ray 2.39A ) 2WMO (X-ray 2.20A ) 3GCG (X-ray 2.30A ) 3QBV (X-ray 2.65A ) 3VHL (X-ray 2.08A ) 4DID (X-ray 2.35A ) 4ITR (X-ray 2.30A ) 4JS0 (X-ray 1.90A ) 4YC7 (X-ray 2.50A ) 4YDH (X-ray 3.80A ) 5CJP (X-ray 2.60A ) 5FI1 (X-ray 3.20A ) 5HZK (X-ray 3.30A ) 5UPK (X-ray 2.40A ) 5UPL (X-ray 3.00A ) 6AJ4 (X-ray 3.26A ) 6AJL (X-ray 3.23A ) 6SIU (X-ray 2.49A ) 6SUP (X-ray 2.00A ) 6TKY (X-ray 2.55A ) 6TKZ (X-ray 2.64A ) 7S0Y (X-ray 2.79A ) |
| DBSNP | rs864309721 |
| Subcellular location [CC] | Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15642749}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15642749}. Midbody {ECO:0000269|PubMed:15642749}. Cell projection, dendrite {ECO:0000250|UniProtKB:P60766}. Note=Localizes to spindle during prometaphase cells. Moves to the central spindle as cells progressed through anaphase to telophase (PubMed:15642749). Localizes at the end of cytokinesis in the intercellular bridge formed between two daughter cells (PubMed:15642749). Its localization is regulated by the activities of guanine nucleotide exchange factor ECT2 and GTPase activating protein RACGAP1 (PubMed:15642749). Colocalizes with NEK6 in the centrosome (PubMed:20873783). In its active GTP-bound form localizes to the leading edge membrane of migrating dendritic cells (By similarity). {ECO:0000250|UniProtKB:P60766, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:20873783}. |
| Mouse PG classification | LPG |
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