Gene Information
Gene NameANK3
OrganismHomo sapiens (Human)
Gene Length4377
Protein NamesAnkyrin-3 (ANK-3) (Ankyrin-G)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000151150 )
Evolutionary StageEukaryota
AlphaFoldDBNA
Gene CardANK3
Uniprot IDQ12955
PfamPF00023; PF12796; PF13637; PF00531; PF17809; PF00791
In ASDno
Allosteric Predictionyes (0.423533459)
Ortholog in AnimalsAlpaca_ ANK3 ( ortholog_one2one )
Dog_ ANK3 ( ortholog_one2one )
Macaque_ ANK3 ( ortholog_one2one )
Mouse_ Ank3 ( ortholog_one2one )
Rat_ Ank3 ( ortholog_one2one )
Rabbit_ ANK3 ( ortholog_one2one )
OhnologsANK1, ANK2
ParalogsANK1, ANK2, ASB7
TissueNA
Tissue SpecificityExpressed in brain, neurons, muscles and other tissues. {ECO:0000269|PubMed:21223964, ECO:0000269|PubMed:7836469}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4O6X  (X-ray  2.10A 
DBSNP rs730882195  rs375050420  rs59021407  rs11599164  rs41274672  rs28932171  rs10821668  rs201547988  rs769573528  rs12261793 
Subcellular location [CC]Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21223964}. Cell projection, axon {ECO:0000250|UniProtKB:O70511}. Cell membrane, sarcolemma {ECO:0000269|PubMed:21223964}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:O70511}. Lysosome {ECO:0000250|UniProtKB:G5E8K5}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O70511}. Note=In skeletal muscle, localized at costameres and neuromuscular junctions. In macrophages, associated with lysosomes. {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:O70511}.;
[Isoform 5]: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8666667}. Golgi apparatus {ECO:0000269|PubMed:8666667}.
Mouse PG classificationNA
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