Gene Information
Gene NameDNAJB6
OrganismHomo sapiens (Human)
Gene Length326
Protein NamesDnaJ homolog subfamily B member 6 (HHDJ1) (Heat shock protein J2) (HSJ-2) (MRJ) (MSJ-1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000105993 )
Evolutionary StageEuk+Bac
AlphaFoldDBO75190
Gene CardDNAJB6
Uniprot IDO75190
PfamPF00226
In ASDno
Allosteric Predictionno (-0.696574839)
Ortholog in AnimalsAlpaca_ DNAJB6 ( ortholog_one2one )
Macaque_ DNAJB6 ( ortholog_one2one )
Mouse_ Dnajb6 ( ortholog_one2one )
Pig_ DNAJB6 ( ortholog_one2one )
Rat_ Dnajb6 ( ortholog_one2many )
Rat_ AABR07006160.1 ( ortholog_one2many )
Rabbit_ DNAJB6 ( ortholog_one2one )
OhnologsDNAJB2
ParalogsDNAJB9, DNAJB14, DNAJB7, DNAJB2, DNAJB12, DNAJB13, DNAJB4, DNAJB1, DNAJB8, DNAJB5, DNAJB11
TissueNA
Tissue SpecificityWidely expressed. Highest levels in testis and brain, and lower levels in heart, spleen, intestine, ovary, placenta, lung, kidney, pancreas, thymus, prostate, skeletal muscle, liver and leukocytes. In testis, expressed in germ cells in the earlier stages of differentiation pathway as well as in spermatids. In brain, expressed at a higher level in hippocampus and thalamus and a lower level in amygdala, substantia nigra, corpus callosum and caudate nucleus. {ECO:0000269|PubMed:10319584, ECO:0000269|PubMed:11896048, ECO:0000269|PubMed:22366786, ECO:0000269|PubMed:9915854}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6U3R  (NMR  -  )  6U3S  (NMR  -  )  7JSQ  (NMR  -  )  7QBY  (NMR  -  ) 
DBSNP rs387907150  rs387907046  rs387907047 
Subcellular location [CC]Cytoplasm, perinuclear region {ECO:0000269|PubMed:10954706}. Nucleus {ECO:0000269|PubMed:10954706}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:22366786}.
Mouse PG classificationLPG
click here to return to the previous page