| Gene Information | |
|---|---|
| Gene Name | FSCN1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 493 |
| Protein Names | Fascin (55 kDa actin-bundling protein) (Singed-like protein) (p55) |
| Target Name | fascin |
| Target Type | Clinical trial target |
| Gene Age | 680 ( ENSG00000075618 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q16658 |
| Gene Card | FSCN1 |
| Uniprot ID | Q16658 |
| Pfam | PF06268 |
| In ASD | yes |
| Allosteric Prediction | yes (0.540787462) |
| Ortholog in Animals | Alpaca_ FSCN1 ( ortholog_one2many ) Dog_ FSCN1 ( ortholog_one2one ) GuineaPig_ FSCN1 ( ortholog_one2one ) Macaque_ FSCN1 ( ortholog_one2one ) Mouse_ Fscn1 ( ortholog_one2one ) Pig_ FSCN1 ( ortholog_one2one ) Rat_ Fscn1 ( ortholog_one2one ) |
| Ohnologs | FSCN2 |
| Paralogs | FSCN2, FSCN3 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1DFC (X-ray 2.90A ) 3LLP (X-ray 1.80A ) 3P53 (X-ray 2.00A ) 4GOV (X-ray 2.20A ) 4GOY (X-ray 2.30A ) 4GP0 (X-ray 2.50A ) 4GP3 (X-ray 2.25A ) 6B0T (X-ray 2.80A ) 6I0Z (X-ray 1.77A ) 6I10 (X-ray 2.10A ) 6I11 (X-ray 1.67A ) 6I12 (X-ray 1.65A ) 6I13 (X-ray 1.79A ) 6I14 (X-ray 1.73A ) 6I15 (X-ray 1.91A ) 6I16 (X-ray 2.00A ) 6I17 (X-ray 1.56A ) 6I18 (X-ray 1.49A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:21706053, ECO:0000269|PubMed:9571235}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21685497}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:3525578, ECO:0000269|PubMed:9571235}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21706053}. Cell projection, filopodium {ECO:0000269|PubMed:20137952, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:3525578}. Cell projection, invadopodium {ECO:0000269|PubMed:20137952}. Cell projection, microvillus {ECO:0000269|PubMed:9571235}. Cell junction {ECO:0000269|PubMed:9571235}. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (By similarity). {ECO:0000250|UniProtKB:Q61553, ECO:0000269|PubMed:21706053}. |
| Mouse PG classification | NA |
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