| Gene Information | |
|---|---|
| Gene Name | TOP3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 862 |
| Protein Names | DNA topoisomerase 3-beta-1 (EC 5.6.2.1) (DNA topoisomerase III beta-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000100038 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O95985 |
| Gene Card | TOP3B |
| Uniprot ID | O95985 |
| Pfam | PF01131; PF01751 |
| In ASD | no |
| Allosteric Prediction | no (-1.348058272) |
| Ortholog in Animals | Alpaca_ TOP3B ( ortholog_one2one ) Dog_ TOP3B ( ortholog_one2one ) GuineaPig_ TOP3B ( ortholog_one2one ) Macaque_ TOP3B ( ortholog_one2one ) Mouse_ Top3b ( ortholog_one2one ) Pig_ TOP3B ( ortholog_one2one ) Rat_ Top3b ( ortholog_one2one ) Rabbit_ TOP3B ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | TOP3A |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is found in testis, heart and skeletal muscle. A 4 kb transcript which probably represents isoform 2 is found in thymus, kidney and pancreas. {ECO:0000269|PubMed:9927731}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001704(Rat);0.013333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5GVC (X-ray 2.44A ) 5GVE (X-ray 3.61A ) |
| DBSNP | rs9610728 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
| click here to return to the previous page | |