Gene Information
Gene NameCD9
OrganismHomo sapiens (Human)
Gene Length228
Protein NamesCD9 antigen (5H9 antigen) (Cell growth-inhibiting gene 2 protein) (Leukocyte antigen MIC3) (Motility-related protein) (MRP-1) (Tetraspanin-29) (Tspan-29) (p24) (CD antigen CD9)
Target Namecd9 antigen
Target TypeNA
Gene Age645 ( ENSG00000010278 )
Evolutionary StageEumetazoa
AlphaFoldDBP21926
Gene CardCD9
Uniprot IDP21926
PfamPF00335
In ASDno
Allosteric Predictionno (-0.278029534)
Ortholog in AnimalsAlpaca_ CD9 ( ortholog_one2one )
Dog_ CD9 ( ortholog_one2one )
GuineaPig_ CD9 ( ortholog_one2one )
Macaque_ CD9 ( ortholog_one2one )
Mouse_ Cd9 ( ortholog_one2one )
Pig_ CD9 ( ortholog_one2one )
Rat_ Cd9 ( ortholog_one2one )
OhnologsCD81, TSPAN2
ParalogsROM1, TSPAN12, CD63, TSPAN10, TSPAN6, TSPAN5, CD37, CD151, TSPAN4, TSPAN1, TSPAN31, UPK1A, TSPAN17, TSPAN11, TSPAN32, TSPAN8, TSPAN13, TSPAN2, CD53, TSPAN9, TSPAN18, CD81, CD82, TSPAN16, TSPAN19, TSPAN7, UPK1B, TSPAN3, TSPAN14, TSPAN15, PRPH2, TSPAN33
TissueNA
Tissue SpecificityDetected in platelets (at protein level) (PubMed:19640571). Expressed by a variety of hematopoietic and epithelial cells (PubMed:19640571). {ECO:0000269|PubMed:19640571}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 6K4J  (X-ray  2.70A  )  6RLO  (X-ray  2.20A  )  6RLR  (X-ray  2.00A  )  6Z1V  (X-ray  1.33A  )  6Z20  (X-ray  2.68A  ) 
DBSNP NA 
Subcellular location [CC]Cell membrane {ECO:0000269|PubMed:19640571};
Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Membrane {ECO:0000269|PubMed:19640571};
Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surface of oocytes. Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO. {ECO:0000250|UniProtKB:P40240}.
Mouse PG classificationNA
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