| Gene Information | |
|---|---|
| Gene Name | CD86 |
| Organism | Homo sapiens (Human) |
| Gene Length | 329 |
| Protein Names | T-lymphocyte activation antigen CD86 (Activation B7-2 antigen) (B70) (BU63) (CTLA-4 counter-receptor B7.2) (FUN-1) (CD antigen CD86) |
| Target Name | t-lymphocyte activation antigen cd86 |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000114013 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P42081 |
| Gene Card | CD86 |
| Uniprot ID | P42081 |
| Pfam | PF07686 |
| In ASD | no |
| Allosteric Prediction | yes (0.857084702) |
| Ortholog in Animals | Alpaca_ CD86 ( ortholog_one2one ) Dog_ CD86 ( ortholog_one2one ) GuineaPig_ CD86 ( ortholog_one2one ) Macaque_ CD86 ( ortholog_one2one ) Mouse_ Cd86 ( ortholog_one2one ) Pig_ CD86 ( ortholog_one2one ) Rat_ Cd86 ( ortholog_one2one ) Rabbit_ CD86 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RFPL4B, CD80, RFPL2, RFPL3, RFPL1, RNF135, RNF152, RFPL4AL1, RFPL4A, SPRYD4, PDCD1LG2, CD274 |
| Tissue | lung, spleen |
| Tissue Specificity | Expressed by activated B-lymphocytes and monocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1I85 (X-ray 3.20A ) 1NCN (X-ray 2.70A ) 5YXK (X-ray 1.90A ) |
| DBSNP | rs9282642 rs2681417 rs1129055 rs9282648 |
| Subcellular location [CC] | Cell membrane; Single-pass type I membrane protein. |
| Mouse PG classification | NA |
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