| Gene Information | |
|---|---|
| Gene Name | CD81 |
| Organism | Homo sapiens (Human) |
| Gene Length | 236 |
| Protein Names | CD81 antigen (26 kDa cell surface protein TAPA-1) (Target of the antiproliferative antibody 1) (Tetraspanin-28) (Tspan-28) (CD antigen CD81) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000110651 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P60033 |
| Gene Card | CD81 |
| Uniprot ID | P60033 |
| Pfam | PF00335 |
| In ASD | no |
| Allosteric Prediction | yes (0.145546851) |
| Ortholog in Animals | Alpaca_ CD81 ( ortholog_one2one ) GuineaPig_ CD81 ( ortholog_one2one ) Macaque_ CD81 ( ortholog_one2one ) Mouse_ Cd81 ( ortholog_one2one ) Pig_ CD81 ( ortholog_one2one ) Rat_ Cd81 ( ortholog_one2one ) |
| Ohnologs | CD9, TSPAN2 |
| Paralogs | ROM1, TSPAN12, CD63, TSPAN10, CD9, TSPAN6, TSPAN5, CD37, CD151, TSPAN4, TSPAN1, TSPAN31, UPK1A, TSPAN17, TSPAN11, TSPAN32, TSPAN8, TSPAN13, TSPAN2, CD53, TSPAN9, TSPAN18, CD82, TSPAN16, TSPAN19, TSPAN7, UPK1B, TSPAN3, TSPAN14, TSPAN15, PRPH2, TSPAN33 |
| Tissue | NA |
| Tissue Specificity | Expressed on B cells (at protein level) (PubMed:20237408). Expressed in hepatocytes (at protein level) (PubMed:12483205). Expressed in monocytes/macrophages (at protein level) (PubMed:12796480). Expressed on both naive and memory CD4-positive T cells (at protein level) (PubMed:22307619). {ECO:0000269|PubMed:12483205, ECO:0000269|PubMed:12796480, ECO:0000269|PubMed:20237408, ECO:0000269|PubMed:22307619}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.187550(Rat);0.105000(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1G8Q (X-ray 1.60A ) 1IV5 (X-ray 2.60A ) 3X0E (X-ray 1.84A ) 5DFV (X-ray 2.80A ) 5DFW (X-ray 2.33A ) 5M2C (X-ray 1.96A ) 5M33 (X-ray 1.28A ) 5M3D (X-ray 2.38A ) 5M3T (X-ray 2.02A ) 5M4R (X-ray 3.10A ) 5TCX (X-ray 2.96A ) 6EJG (X-ray 2.82A ) 6EJM (X-ray 2.15A ) 6EK2 (X-ray 2.65A ) 6U9S (X-ray 2.40A ) 7JIC (EM 3.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:1695320, ECO:0000269|PubMed:20237408, ECO:0000269|PubMed:22307619, ECO:0000269|PubMed:2398277, ECO:0000269|PubMed:26354436}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000269|PubMed:20375010}. |
| Mouse PG classification | LPG |
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