| Gene Information | |
|---|---|
| Gene Name | CAMK2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 666 |
| Protein Names | Calcium/calmodulin-dependent protein kinase type II subunit beta (CaM kinase II subunit beta) (CaMK-II subunit beta) (EC 2.7.11.17) |
| Target Name | calcium/calmodulin-dependent protein kinase type ii subunit beta |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000058404 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q13554 |
| Gene Card | CAMK2B |
| Uniprot ID | Q13554 |
| Pfam | PF08332; PF00069 |
| In ASD | no |
| Allosteric Prediction | yes (1.141773391) |
| Ortholog in Animals | Alpaca_ CAMK2B ( ortholog_one2one ) Dog_ CAMK2B ( ortholog_one2one ) GuineaPig_ CAMK2B ( ortholog_one2one ) Macaque_ CAMK2B ( ortholog_one2one ) Mouse_ Camk2b ( ortholog_one2one ) Pig_ CAMK2B ( ortholog_one2one ) Rat_ Camk2b ( ortholog_one2one ) |
| Ohnologs | CAMK2G, CAMK2D |
| Paralogs | DCLK3, PHKG1, MYLK4, CAMKK1, CAMKK2, DCLK2, PSKH1, PNCK, CAMK1D, CAMKV, CAMK1, STK11, STK33, PHKG2, DCLK1, PSKH2, CAMK2G, MYLK2, CAMK2D, CAMK2A, MYLK3, CAMK1G |
| Tissue | brain, cerebral.cortex, adrenal.gland, heart |
| Tissue Specificity | Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle. {ECO:0000269|PubMed:16690701}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3BHH (X-ray 2.40A ) 7URW (X-ray 3.11A ) 7URY (X-ray 2.64A ) 7URZ (X-ray 3.45A ) |
| DBSNP | rs1554402092 rs1554389088 rs1554387293 rs1554386687 rs1554385203 rs1554385111 rs555460132 rs35452727 |
| Subcellular location [CC] | Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21529938}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:21529938}; Peripheral membrane protein {ECO:0000269|PubMed:21529938}; Cytoplasmic side {ECO:0000269|PubMed:21529938}. Synapse {ECO:0000250|UniProtKB:P08413}. Note=In slow-twitch muscle, evenly distributed between longitudinal SR and junctional SR. |
| Mouse PG classification | NA |
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